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Summary Expression Phenotypes Gene Literature (44) GO Terms (7) Nucleotides (61) Proteins (42) Interactants (104) Wiki
XB-GENEPAGE-986529

Papers associated with antxr1



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Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex., Kundu LR, Kumata Y, Kakusho N, Watanabe S, Furukohri A, Waga S, Seki M, Masai H, Enomoto T, Tada S., Nucleic Acids Res. September 1, 2010; 38 (16): 5409-18.              

CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells., Yoshida K, Sugimoto N, Iwahori S, Yugawa T, Narisawa-Saito M, Kiyono T, Fujita M., J Cell Sci. January 15, 2010; 123 (Pt 2): 225-35.

Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase., Lindsey-Boltz LA, Serçin O, Choi JH, Sancar A., J Biol Chem. November 27, 2009; 284 (48): 33107-14.

The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways., Sobeck A, Stone S, Landais I, de Graaf B, Hoatlin ME., J Biol Chem. September 18, 2009; 284 (38): 25560-8.

An ATM and ATR dependent pathway targeting centrosome dependent spindle assembly., Brown N, Costanzo V., Cell Cycle. July 1, 2009; 8 (13): 1997-2001.

An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63., Smith E, Dejsuphong D, Balestrini A, Hampel M, Lenz C, Takeda S, Vindigni A, Costanzo V., Nat Cell Biol. March 1, 2009; 11 (3): 278-85.

DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts., Labit H, Perewoska I, Germe T, Hyrien O, Marheineke K., Nucleic Acids Res. October 1, 2008; 36 (17): 5623-34.              

Probing ATR activation with model DNA templates., Cimprich KA., Cell Cycle. October 1, 2007; 6 (19): 2348-54.

The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR., Lee J, Lee J, Kumagai A, Dunphy WG., J Biol Chem. September 21, 2007; 282 (38): 28036-44.

Non-catalytic function for ATR in the checkpoint response., McSherry TD, Kitazono AA, Javaheri A, Kron SJ, Mueller PR., Cell Cycle. August 15, 2007; 6 (16): 2019-30.

Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM., Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., J Biol Chem. June 15, 2007; 282 (24): 17501-6.

Linking PCNA-dependent replication and ATR by human Claspin., Brondello JM, Ducommun B, Fernandez A, Lamb NJ., Biochem Biophys Res Commun. March 23, 2007; 354 (4): 1028-33.

Analyzing the ATR-mediated checkpoint using Xenopus egg extracts., Lupardus PJ, Van C, Cimprich KA., Methods. February 1, 2007; 41 (2): 222-31.

The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1., Hashimoto Y, Tsujimura T, Sugino A, Takisawa H., Genes Cells. September 1, 2006; 11 (9): 993-1007.

Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells., Rodríguez-Bravo V, Guaita-Esteruelas S, Florensa R, Bachs O, Agell N., Cancer Res. September 1, 2006; 66 (17): 8672-9.

Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling., Bomgarden RD, Lupardus PJ, Soni DV, Yee MC, Ford JM, Cimprich KA., EMBO J. June 7, 2006; 25 (11): 2605-14.

Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling., Yan S, Lindsay HD, Michael WM., J Cell Biol. April 24, 2006; 173 (2): 181-6.          

ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks., Trenz K, Smith E, Smith S, Costanzo V., EMBO J. April 19, 2006; 25 (8): 1764-74.

Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus., Lupardus PJ, Cimprich KA., Mol Biol Cell. April 1, 2006; 17 (4): 1559-69.

TopBP1 activates the ATR-ATRIP complex., Kumagai A, Lee J, Lee J, Yoo HY, Dunphy WG., Cell. March 10, 2006; 124 (5): 943-55.

TOPping up ATR activity., Bartek J, Mailand N., Cell. March 10, 2006; 124 (5): 888-90.

Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint., Petersen P, Chou DM, You Z, Hunter T, Walter JC, Walter G., Mol Cell Biol. March 1, 2006; 26 (5): 1997-2011.

Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP., Kim SM, Kumagai A, Lee J, Lee J, Dunphy WG., J Biol Chem. November 18, 2005; 280 (46): 38355-64.

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint., Byun TS, Pacek M, Yee MC, Walter JC, Cimprich KA., Genes Dev. May 1, 2005; 19 (9): 1040-52.

ATM and ATR check in on origins: a dynamic model for origin selection and activation., Shechter D, Gautier J., Cell Cycle. February 1, 2005; 4 (2): 235-8.

Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses., Yoo HY, Shevchenko A, Shevchenko A, Dunphy WG., J Biol Chem. December 17, 2004; 279 (51): 53353-64.

Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus., Luciani MG, Oehlmann M, Blow JJ., J Cell Sci. December 1, 2004; 117 (Pt 25): 6019-30.

Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1., Kumagai A, Kim SM, Dunphy WG., J Biol Chem. November 26, 2004; 279 (48): 49599-608.

Xenopus Cds1 is regulated by DNA-dependent protein kinase and ATR during the cell cycle checkpoint response to double-stranded DNA ends., McSherry TD, Mueller PR., Mol Cell Biol. November 1, 2004; 24 (22): 9968-85.

Control of replication origin density and firing time in Xenopus egg extracts: role of a caffeine-sensitive, ATR-dependent checkpoint., Marheineke K, Hyrien O., J Biol Chem. July 2, 2004; 279 (27): 28071-81.

ATR and ATM regulate the timing of DNA replication origin firing., Shechter D, Costanzo V, Gautier J., Nat Cell Biol. July 1, 2004; 6 (7): 648-55.

Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation., Katsuragi Y, Sagata N., Mol Biol Cell. April 1, 2004; 15 (4): 1680-9.

Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation., Jeong SY, Kumagai A, Lee J, Lee J, Dunphy WG., J Biol Chem. November 21, 2003; 278 (47): 46782-8.

Cut5 is required for the binding of Atr and DNA polymerase alpha to genotoxin-damaged chromatin., Parrilla-Castellar ER, Karnitz LM., J Biol Chem. November 14, 2003; 278 (46): 45507-11.

ATM/ATR-independent inhibition of cyclin B accumulation in response to hydroxyurea in nontransformed cell lines is altered in tumour cell lines., Florensa R, Bachs O, Agell N., Oncogene. November 13, 2003; 22 (51): 8283-92.

Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17., Lee J, Lee J, Kumagai A, Dunphy WG., Mol Cell. February 1, 2003; 11 (2): 329-40.

An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication., Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J., Mol Cell. January 1, 2003; 11 (1): 203-13.

Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366., Sapkota GP, Deak M, Kieloch A, Morrice N, Goodarzi AA, Smythe C, Shiloh Y, Lees-Miller SP, Alessi DR., Biochem J. December 1, 2002; 368 (Pt 2): 507-16.

A requirement for replication in activation of the ATR-dependent DNA damage checkpoint., Lupardus PJ, Byun T, Yee MC, Hekmat-Nejad M, Cimprich KA., Genes Dev. September 15, 2002; 16 (18): 2327-32.

The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint., You Z, Kong L, Newport J., J Biol Chem. July 26, 2002; 277 (30): 27088-93.

Aphidicolin triggers a block to replication origin firing in Xenopus egg extracts., Marheineke K, Hyrien O., J Biol Chem. May 18, 2001; 276 (20): 17092-100.

Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint., Hekmat-Nejad M, You Z, Yee MC, Newport JW, Cimprich KA., Curr Biol. December 1, 2000; 10 (24): 1565-73.

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts., Guo Z, Kumagai A, Wang SX, Dunphy WG., Genes Dev. November 1, 2000; 14 (21): 2745-56.

Drosophila dSmad2 and Atr-I transmit activin/TGFbeta signals., Das P, Inoue H, Baker JC, Beppu H, Kawabata M, Harland RM, Miyazono K, Padgett RW., Genes Cells. February 1, 1999; 4 (2): 123-34.  

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