| Monarch Ortholog Phenotypes
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Human (3 sources):
Nephrolithiasis,
Renal tubular acidosis,
Sensorineural hearing impairment
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Mouse (30 sources):
abnormal Reissner membrane morphology,
abnormal cochlea morphology,
abnormal cochlear endolymph ionic homeostasis,
abnormal membranous labyrinth morphology,
abnormal olfactory system physiology,
abnormal organ of Corti morphology,
abnormal pH regulation,
abnormal prepulse inhibition,
abnormal renal transport,
abnormal response to novel odor,
abnormal spiral ligament fibrocyte morphology,
abnormal spiral limbus morphology,
abnormal type I spiral ligament fibrocytes,
abnormal type III spiral ligament fibrocytes,
bidirectional circling,
decreased circulating bicarbonate level,
decreased cochlear outer hair cell number,
decreased endocochlear potential,
decreased otolith number,
decreased prepulse inhibition,
decreased urine osmolality,
dilated endolymphatic duct,
dilated scala media,
head tilt,
hearing/vestibular/ear phenotype,
increased or absent threshold for auditory brainstem response,
increased urine pH,
skeleton phenotype,
small scala tympani,
thin spiral ligament
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.