| Monarch Ortholog Phenotypes
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Human (41 sources):
Abnormal central microtubular pair morphology of respiratory motile cilia,
Abnormality of the digestive system,
Abnormality of the immune system,
Airway obstruction,
Asplenia,
Asthma,
Atelectasis,
Bronchiectasis,
Chronic bronchitis,
Chronic otitis media,
Chronic rhinitis,
Chronic sinusitis,
Ciliary dyskinesia,
Clubbing of fingers,
Conductive hearing impairment,
Corneal dystrophy,
Cough,
Delayed speech and language development,
Ectopic pregnancy,
Exercise intolerance,
Glue ear,
Halitosis,
Headache,
Hydrocephalus,
Immotile cilia,
Immotile sperm,
Impaired nasal mucociliary clearance,
Infertility,
Miscarriage,
Nasal polyposis,
Pectus excavatum,
Pneumonia,
Recurrent respiratory infections,
Reduced sperm motility,
Respiratory distress,
Rhinitis,
Scoliosis,
Short stature,
Situs inversus totalis,
Tachypnea,
Ventriculomegaly
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Mouse (19 sources):
abnormal brain ependyma morphology,
abnormal brain ependyma motile cilium morphology,
abnormal brain ependyma motile cilium physiology,
abnormal brain vasculature morphology,
abnormal cerebrospinal fluid flow,
abnormal locomotor activation,
decreased survivor rate,
domed cranium,
enlarged cranium,
enlarged lateral ventricles,
growth/size/body region phenotype,
increased brain size,
increased microglial cell activation,
increased oligodendrocyte number,
microgliosis,
nervous system phenotype,
postnatal lethality, incomplete penetrance,
preweaning lethality, incomplete penetrance,
thin cerebral cortex
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.