tnfaip3 Phenotypes

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Phenotypes

Gene Literature (1)

Nucleotides (22)

Interactants (77)

XB-GENEPAGE-6460207

Gene Symbol: tnfaip3 Gene Name: TNF alpha induced protein 3

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: tnfaip3 assayed (3 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (13 sources): Anterior uveitis, Antinuclear antibody positivity, Colitis, Eczematoid dermatitis, Genital ulcers, Hemolytic anemia, Lupus anticoagulant, Lymphopenia, Oral ulcer, Polyarticular arthritis, Recurrent fever, Skin rash, Thrombocytopenia [+]
Mouse (56 sources): abnormal B cell activation, abnormal B-1a B cell morphology, abnormal blood cell morphology/development, abnormal circulating cytokine level, abnormal circulating interleukin level, abnormal myelopoiesis, abnormal response/metabolism to endogenous compounds, abnormal small intestine crypts of Lieberkuhn morphology, decreased B cell apoptosis, decreased B-1a cell number, decreased B-1b cell number, decreased body size, decreased colon length, decreased interleukin-6 secretion, decreased marginal zone B cell number, decreased mature B cell number, enlarged lymph nodes, growth/size/body region phenotype, hematopoietic system phenotype, immune system phenotype, impaired adaptive thermogenesis, increased B cell proliferation, increased CD4-positive, alpha beta T cell number, increased CD8-positive, alpha-beta T cell number, increased IgG2a level, increased anti-nuclear antigen antibody level, increased apoptosis, increased autoantibody level, increased circulating alanine transaminase level, increased circulating aspartate transaminase level, increased circulating interferon-gamma level, increased circulating interleukin-1 beta level, increased circulating interleukin-6 level, increased circulating tumor necrosis factor level, increased enterocyte apoptosis, increased follicular B cell number, increased germinal center B cell number, increased granulocyte number, increased immature B cell number, increased interleukin-6 secretion, increased macrophage cell number, increased myeloid cell number, increased myeloid cell number in bone marrow, increased plasma cell number, increased sensitivity to induced morbidity/mortality, increased sensitivity to xenobiotic induced morbidity/mortality, increased splenocyte number, increased susceptibility to autoimmune disorder, increased susceptibility to induced colitis, increased susceptibility to weight loss, myeloid hyperplasia, pale spleen, postnatal lethality, incomplete penetrance, premature death, thick dermal layer, thymus atrophy [+]
View all ortholog results at Monarch