| Monarch Ortholog Phenotypes
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Human (40 sources):
Abnormality of the digestive system,
Abnormality of the immune system,
Absent inner and outer dynein arms,
Airway obstruction,
Asplenia,
Asthma,
Atelectasis,
Bronchiectasis,
Chronic bronchitis,
Chronic otitis media,
Chronic sinusitis,
Ciliary dyskinesia,
Clubbing of fingers,
Conductive hearing impairment,
Corneal dystrophy,
Cough,
Delayed speech and language development,
Ectopic pregnancy,
Glue ear,
Halitosis,
Headache,
Hydrocephalus,
Immotile cilia,
Impaired nasal mucociliary clearance,
Infertility,
Miscarriage,
Nasal polyposis,
Pectus excavatum,
Pneumonia,
Recurrent otitis media,
Recurrent respiratory infections,
Recurrent sinusitis,
Reduced sperm motility,
Respiratory distress,
Respiratory insufficiency due to defective ciliary clearance,
Rhinitis,
Scoliosis,
Situs inversus totalis,
Tachypnea,
Ventriculomegaly
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Mouse (11 sources):
abnormal azygos vein topology,
abnormal brain ependyma motile cilium physiology,
abnormal left-right axis patterning,
abnormal lung lobe morphology,
abnormal motile primary cilium physiology,
domed cranium,
immotile respiratory cilia,
immotile sperm,
premature death,
prenatal lethality, incomplete penetrance,
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.