zap70 Phenotypes

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Phenotypes

Gene Literature (0)

Nucleotides (72)

Interactants (13)

XB-GENEPAGE-956408

Gene Symbol: zap70 Gene Name: zeta chain of T cell receptor associated protein kinase 70

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (39 sources): Abnormality of the lymph nodes, Absence of CD8-positive T cells, Autoimmune hemolytic anemia, Autoimmune thrombocytopenia, Autoimmunity, Chronic diarrhea, Chronic mucocutaneous candidiasis, Chronic oral candidiasis, Colitis, Decreased lymphocyte proliferation in response to mitogen, Decreased proportion of CD8-positive T cells, Diarrhea, Eosinophilia, Failure to thrive, Hepatomegaly, Hepatosplenomegaly, Lymphadenitis, Lymphadenopathy, Lymphocytosis, Lymphoma, Lymphoproliferative disorder, Minimal change glomerulonephritis, Nephrotic syndrome, Panhypogammaglobulinemia, Pneumonia, Proteinuria, Recurrent bacterial infections, Recurrent bacterial skin infections, Recurrent candida infections, Recurrent infection of the gastrointestinal tract, Recurrent mycobacterial infections, Recurrent opportunistic infections, Recurrent upper and lower respiratory tract infections, Recurrent viral infections, Skin rash, Splenomegaly, Stomatitis, Stroke, obsolete Eczematoid dermatitis [+]
Mouse (46 sources): abnormal CD4-positive, alpha beta T cell morphology, abnormal CD8-positive, alpha-beta T cell differentiation, abnormal T cell activation, abnormal T cell clonal deletion, abnormal T cell differentiation, abnormal T cell selection, abnormal T cell subpopulation ratio, abnormal class switch recombination, abnormal double-positive T cell morphology, abnormal humoral immune response, abnormal lymph node cell ratio, abnormal positive T cell selection, abnormal regulatory T cell number, abnormal regulatory T cell physiology, abnormal splenic cell ratio, abnormal thymocyte activation, abnormal thymus cell ratio, absent CD4-positive, alpha beta T cells, absent T cells, arrested T cell differentiation, chronic joint inflammation, decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number, decreased CD4-positive, alpha beta T cell number, decreased CD8-positive, naive alpha-beta T cell number, decreased T cell proliferation, decreased interleukin-2 secretion, decreased regulatory T cell number, decreased susceptibility to induced arthritis, immune system phenotype, impaired hematopoiesis, impaired humoral immune response, increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number, increased IgG1 level, increased IgG2b level, increased activated T cell number, increased autoantibody level, increased central memory CD4-positive, alpha-beta T cell number, increased central memory CD8 positive, alpha-beta T cell number, increased double-positive T cell number, increased effector memory CD4-positive, alpha-beta T cell number, increased interleukin-17 secretion, increased memory T cell number, increased susceptibility to induced arthritis, mixed cellular infiltration to dermis, no abnormal phenotype detected, small lymph nodes [+]
View all ortholog results at Monarch