| Monarch Ortholog Phenotypes
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Human (1 source):
Age-related nuclear cataract
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Mouse (31 sources):
abnormal male germ cell apoptosis,
abnormal motor capabilities/coordination/movement,
abnormal myelopoiesis,
abnormal seminiferous tubule morphology,
abnormal spermatid morphology,
abnormal tumor incidence,
absent common myeloid progenitor cells,
behavior/neurological phenotype,
decreased hematopoietic stem cell number,
decreased locomotor activity,
decreased male germ cell number,
decreased testis weight,
hematopoietic system phenotype,
homeostasis/metabolism phenotype,
increased T cell derived lymphoma incidence,
increased hepatocellular carcinoma incidence,
increased liver tumor incidence,
increased sensitivity to xenobiotic induced morbidity/mortality,
increased spleen red pulp amount,
multinucleated giant male germ cells,
nervous system phenotype,
no abnormal phenotype detected,
perinatal lethality, incomplete penetrance,
postnatal lethality, incomplete penetrance,
premature death,
reduced male fertility,
seminiferous tubule degeneration,
short stride length,
skeleton phenotype,
testis degeneration,
vision/eye phenotype
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.