Decreased activity of mitochondrial respiratory chain, Dementia, Depletion of mitochondrial DNA in liver, Depression, Distal muscle weakness, Dysphagia, Dysphonia, Elevated circulating creatine kinase concentration, Elevated circulating hepatic transaminase concentration, Encephalopathy, Failure to thrive, Feeding difficulties in infancy, Generalized aminoaciduria, Generalized hypotonia, Growth delay, Hepatic failure, Hepatic steatosis, Hepatocellular necrosis, Hepatomegaly, Hyperbilirubinemia, Hyperreflexia, Hypoalbuminemia, Hypoglycemia, Hyporeflexia, Hypothermia, Hypotonia, Increased circulating lactate concentration, Jaundice, Lactic acidosis, Limb-girdle muscle atrophy, Limb-girdle muscle weakness, Lower limb muscle weakness, Microcephaly, Micronodular cirrhosis, Mitochondrial myopathy, Muscle spasm, Myalgia, Nystagmus, Optic atrophy, Pelvic girdle muscle weakness, Peripheral axonal neuropathy, Periportal fibrosis, Polyneuropathy, Portal hypertension, Progressive external ophthalmoplegia, Proximal muscle weakness, Ptosis, Ragged-red muscle fibers, Seizure, Sensorineural hearing impairment, Sensory axonal neuropathy, Skeletal muscle atrophy, Splenomegaly, Strabismus, Thrombocytopenia, Viral infection-induced rhabdomyolysis, Vomiting

decreased mitochondrial DNA content, decreased vertical activity, dilated mitochondria, enhanced liver regeneration, grizzled coat color, increased circulating alanine transaminase level, increased circulating aspartate transaminase level, increased grip strength, increased heart weight, increased hepatocyte karyomegaly, increased hepatocyte proliferation, increased kidney weight, increased liver weight, oxidative stress, premature death