| Monarch Ortholog Phenotypes
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Human (19 sources):
Abnormality of eye movement,
Abnormality of the mouth,
Aggressive behavior,
Ataxia,
Bilateral tonic-clonic seizure,
Dysarthria,
EEG with generalized polyspikes,
EEG with polyspike wave complexes,
Episodic ataxia,
Febrile seizure (within the age range of 3 months to 6 years),
[+]
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Mouse (40 sources):
abnormal CD4-positive, alpha-beta T cell physiology,
abnormal CNS synaptic transmission,
abnormal Peyer's patch germinal center morphology,
abnormal brain wave pattern,
abnormal eye electrophysiology,
abnormal locomotor activation,
abnormal locomotor behavior,
abnormal motor capabilities/coordination/movement,
abnormal neuromuscular synapse morphology,
abnormal thymus involution,
absent corpus luteum,
absent thymus corticomedullary boundary,
behavior/neurological phenotype,
circling,
clonic seizures,
convulsive seizures,
decreased Peyer's patch number,
decreased body size,
decreased double-positive T cell number,
decreased interferon-gamma secretion,
decreased interleukin-2 secretion,
decreased locomotor activity,
enlarged lymph nodes,
facial muscle spasm,
hearing/vestibular/ear phenotype,
impaired behavioral response to xenobiotic,
impaired limb coordination,
impaired righting response,
increased IgG1 level,
increased length of allograft survival,
increased startle reflex,
nervous system phenotype,
pituitary gland hyperplasia,
premature death,
reduced fertility,
small Peyer's patches,
small spleen,
small thymus,
tonic seizures,
vision/eye phenotype
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.