herc2 Phenotypes

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Phenotypes

Gene Literature (2)

Nucleotides (205)

Interactants (237)

XB-GENEPAGE-1012658

Gene Symbol: herc2 Gene Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: herc2 assayed (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (23 sources): Aggressive behavior, Astigmatism, Autistic behavior, Blue irides, Delayed ability to walk, Delayed speech and language development, Diminished ability to concentrate, Echolalia, Febrile seizure (within the age range of 3 months to 6 years), Generalized hypotonia, Global developmental delay, Hyperactivity, Intellectual disability, Mandibular prognathia, Narrow palate, Neonatal hypotonia, Plagiocephaly, Recurrent hand flapping, Sandal gap, Seizure, Self-mutilation, Strabismus, Unsteady gait [+]
Mouse (16 sources): Purkinje cell axonal dystrophy, Purkinje cell degeneration, abnormal Purkinje cell dendrite morphology, abnormal autophagy, abnormal lysosome morphology, abnormal spermatid morphology, decreased body fat mass, decreased body size, decreased corpora lutea number, decreased lean body mass, decreased male germ cell number, embryonic lethality, complete penetrance, nervous system phenotype, postnatal lethality, incomplete penetrance, prenatal lethality, complete penetrance, reduced female fertility [+]
View all ortholog results at Monarch