Monarch Ortholog Phenotypes
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Human (62 sources):
Abnormal circulating lipid concentration,
Abnormal morphology of female internal genitalia,
Abnormal rib cage morphology,
Abnormality of movement,
Abnormality of the mouth,
Abnormality of the uterus,
Absent axillary hair,
Absent facial hair,
Absent pubic hair,
Absent vas deferens,
Ambiguous genitalia, male,
Aplasia of the uterus,
Aplasia/Hypoplasia of the fallopian tube,
Aplasia/hypoplasia of the uterus,
Azoospermia,
Bifid scrotum,
Blind vagina,
Bulbar palsy,
Calf muscle hypertrophy,
Cryptorchidism,
Decreased fertility,
Delayed puberty,
Dysarthria,
Dysphagia,
Dysphonia,
Elevated circulating creatine kinase concentration,
Elevated circulating follicle stimulating hormone level,
Elevated circulating luteinizing hormone level,
Erectile dysfunction,
Fasciculations,
Female external genitalia in individual with 46,XY karyotype,
Female pseudohermaphroditism,
Gait disturbance,
Gonadal neoplasm,
Growth abnormality,
Gynecomastia,
Hypogonadism,
Hyporeflexia,
Hypospadias,
Hypotonia,
Infertility,
Labial hypoplasia,
Limb muscle weakness,
Male infertility,
Male pseudohermaphroditism,
Micropenis,
Muscle spasm,
Neoplasm,
Nephrolithiasis,
Osteoporosis,
Perineal hypospadias,
Peripheral neuropathy,
Primary amenorrhea,
Sensory neuropathy,
Skeletal muscle atrophy,
Sparse axillary hair,
Sparse pubic hair,
Testicular atrophy,
Testicular gonadoblastoma,
Testicular neoplasm,
Tremor,
Type II diabetes mellitus
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Mouse (118 sources):
Leydig cell hypertrophy,
abnormal Sertoli cell barrier function,
abnormal Sertoli cell barrier morphology,
abnormal Sertoli cell morphology,
abnormal adipose tissue amount,
abnormal adult Leydig cell differentiation,
abnormal anogenital distance,
abnormal bone marrow cell number,
abnormal branching of the mammary ductal tree,
abnormal caput epididymis morphology,
abnormal cauda epididymis morphology,
abnormal copulatory plug formation,
abnormal corpus epididymis morphology,
abnormal epididymis epithelium morphology,
abnormal epididymis morphology,
abnormal erythropoiesis,
abnormal external male genitalia morphology,
abnormal fat cell morphology,
abnormal female reproductive system morphology,
abnormal foreskin morphology,
abnormal gametogenesis,
abnormal lactation,
abnormal long bone metaphysis morphology,
abnormal male germ cell apoptosis,
abnormal mammary gland morphology,
abnormal meiosis,
abnormal myocardial fiber morphology,
abnormal nursing,
abnormal peritubular myoid cell morphology,
abnormal postnatal growth,
abnormal prostate gland anterior lobe morphology,
abnormal prostate gland epithelium morphology,
abnormal prostate gland morphology,
abnormal reproductive system development,
abnormal secondary sex determination,
abnormal seminal vesicle epithelium morphology,
abnormal seminal vesicle morphology,
abnormal seminal vesicle muscle layer morphology,
abnormal seminiferous tubule morphology,
abnormal sensory neuron innervation pattern,
abnormal sperm flagellum morphology,
abnormal sperm number,
abnormal spermatid morphology,
abnormal spermatocyte morphology,
abnormal spermatogonia morphology,
abnormal tumor morphology,
absent Wolffian ducts,
absent epididymis,
absent external male genitalia,
absent prostate gland,
absent seminal vesicle,
arrest of male meiosis,
arrest of spermatogenesis,
behavior/neurological phenotype,
blind vagina,
cardiac interstitial fibrosis,
coiled sperm flagellum,
decreased Leydig cell number,
decreased Sertoli cell number,
decreased epididymis weight,
decreased germ cell number,
decreased gonadal fat pad weight,
decreased heart weight,
decreased incidence of tumors by chemical induction,
decreased litter size,
decreased male germ cell number,
decreased ovary weight,
decreased oviduct weight,
decreased prostate gland weight,
decreased seminal vesicle weight,
decreased susceptibility to weight gain,
decreased testis weight,
decreased uterus weight,
decreased ventricle muscle contractility,
enlarged prostate gland,
enlarged seminiferous tubules,
enlarged thymus,
epididymis epithelium degeneration,
growth/size/body region phenotype,
hairpin sperm flagellum,
homeostasis/metabolism phenotype,
impaired fertilization,
increased bone ossification,
increased brown adipose tissue amount,
increased circulating glucose level,
increased circulating pituitary hormone level,
increased gonadal fat pad weight,
increased immature B cell number,
increased interscapular fat pad weight,
increased liver triglyceride level,
increased mesenteric fat pad weight,
increased omental fat pad weight,
increased osteoclast cell number,
increased renal fat pad weight,
increased susceptibility to weight gain,
increased testis tumor incidence,
increased triglyceride level,
increased white adipose tissue amount,
kinked sperm flagellum,
no abnormal phenotype detected,
premature acrosome reaction,
preneoplasia,
reduced male fertility,
reproductive system phenotype,
secondary sex reversal,
seminiferous tubule degeneration,
short perineum,
small heart,
small myocardial fiber,
small penis,
small prostate gland,
small prostate gland anterior lobe,
small prostate gland ventral lobe,
small seminal vesicle,
small seminiferous tubules,
testis degeneration,
testis hypoplasia,
thin ventricular wall
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