| Monarch Ortholog Phenotypes
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Human (2 sources):
Drusen,
Foveal hyperpigmentation
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Mouse (41 sources):
abnormal brain development,
abnormal c-wave shape,
abnormal cell adhesion,
abnormal dermal layer morphology,
abnormal embryonic tissue morphology,
abnormal epidermis stratum basale morphology,
abnormal extraembryonic tissue morphology,
abnormal eye electrophysiology,
abnormal hair follicle development,
abnormal keratinocyte morphology,
abnormal limb development,
abnormal mammary gland epithelium morphology,
abnormal mammary gland epithelium physiology,
abnormal milk composition,
abnormal mitosis,
abnormal neuron differentiation,
abnormal retina outer limiting membrane morphology,
abnormal retina pigment epithelium morphology,
abnormal rod electrophysiology,
abnormal skeleton development,
absent blastocoele,
absent inner cell mass,
absent vibrissae,
decreased a-wave amplitude,
decreased b-wave amplitude,
decreased width of hypertrophic chondrocyte zone,
delayed intramembranous bone ossification,
embryonic lethality before implantation, complete penetrance,
epidermal desquamation,
increased brain weight,
increased keratinocyte proliferation,
increased mammary gland apoptosis,
maternal effect,
pointed snout,
postnatal lethality, complete penetrance,
retina cone cell degeneration,
retina photoreceptor degeneration,
retina rod cell degeneration,
retina spots,
thick epidermis stratum basale,
thin retina outer nuclear layer
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.