mdm2 Phenotypes

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Phenotypes

Gene Literature (24)

Nucleotides (243)

Interactants (247)

XB-GENEPAGE-482710

Gene Symbol: mdm2 Gene Name: MDM2 proto-oncogene

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: mdm2 assayed (7 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (12 sources): Breast carcinoma, Lymphoma, Melanoma, Neoplasm, Neoplasm of the adrenal cortex, Neoplasm of the colon, Neoplasm of the nervous system, Neoplasm of the pancreas, Neoplasm of the skin, Osteosarcoma, Progressive encephalopathy, Sarcoma [+]
Mouse (51 sources): abnormal cell cycle checkpoint function, abnormal embryonic tissue morphology, abnormal gastrulation, abnormal hematopoietic system physiology, abnormal kidney morphology, cellular phenotype, decreased apoptosis, decreased bone marrow cell number, decreased cell proliferation, decreased cellular sensitivity to ionizing radiation, decreased double-negative T cell number, decreased double-positive T cell number, decreased embryo size, decreased erythrocyte cell number, decreased granulocyte number, decreased immature B cell number, decreased kidney weight, decreased liver weight, decreased mortality induced by ionizing radiation, decreased spleen weight, decreased thymocyte apoptosis, decreased thymocyte number, decreased thymus weight, embryonic growth retardation, embryonic lethality between implantation and somite formation, complete penetrance, embryonic lethality during organogenesis, complete penetrance, embryonic lethality, complete penetrance, empty decidua capsularis, growth/size/body region phenotype, immune system phenotype, increased B cell derived lymphoma incidence, increased T cell derived lymphoma incidence, increased adenocarcinoma incidence, increased cardiomyocyte apoptosis, increased cell proliferation, increased cellular sensitivity to ionizing radiation, increased fibroblast proliferation, increased foot pad pigmentation, increased lymphoma incidence, increased mammary adenocarcinoma incidence, increased mortality induced by gamma-irradiation, increased mortality induced by ionizing radiation, increased pituitary adenoma incidence, increased salivary gland tumor incidence, increased tumor incidence, no abnormal phenotype detected, premature death, prenatal lethality, complete penetrance, prenatal lethality, incomplete penetrance, small heart, thin myocardium [+]
View all ortholog results at Monarch