| Monarch Ortholog Phenotypes
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Human (12 sources):
Anemia,
Chronic diarrhea,
Chronic oral candidiasis,
Conjunctivitis,
Decreased circulating antibody level,
Failure to thrive,
Immunodeficiency,
Intermittent thrombocytopenia,
Meningitis,
Neutropenia,
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Mouse (42 sources):
abnormal colon morphology,
abnormal duodenum morphology,
abnormal embryonic erythrocyte morphology,
abnormal embryonic erythropoiesis,
abnormal enterocyte morphology,
abnormal enterocyte proliferation,
abnormal erythrocyte cell number,
abnormal erythropoiesis,
abnormal hemoglobin content,
abnormal intestinal mineral absorption,
abnormal iron level,
abnormal mean corpuscular hemoglobin,
abnormal mean corpuscular volume,
abnormal red blood cell distribution width,
abnormal vocalization,
blunted small intestinal villi,
decreased body size,
decreased circulating iron level,
decreased colon length,
decreased hemoglobin content,
decreased liver iron level,
decreased mean corpuscular hemoglobin,
decreased mean corpuscular volume,
decreased spleen iron level,
distended stomach,
embryo tissue necrosis,
embryonic growth retardation,
embryonic lethality prior to tooth bud stage,
embryonic lethality, complete penetrance,
hematopoietic system phenotype,
hypoxia,
increased apoptosis,
increased circulating iron level,
increased erythrocyte cell number,
increased heart iron level,
increased red blood cell distribution width,
kinked neural tube,
microcytosis,
no abnormal phenotype detected,
postnatal lethality, complete penetrance,
premature death,
preweaning lethality, complete penetrance
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.