| Monarch Ortholog Phenotypes
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Human (11 sources):
Abnormality of metabolism/homeostasis,
Abnormality of the face,
Abnormality of the immune system,
Decreased response to growth hormone stimulation test,
Delayed skeletal maturation,
Growth delay,
Hypoglycemia,
Impaired growth-hormone response to insulin stimulation test,
Pituitary dwarfism,
Severe short stature,
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Mouse (31 sources):
abnormal adenohypophysis morphology,
abnormal fasting circulating glucose level,
abnormal grip strength,
abnormal heart weight,
abnormal kidney morphology,
abnormal locomotor activation,
absent lactotrophs,
absent somatotrophs,
decreased brain weight,
decreased fasting circulating glucose level,
decreased grip strength,
decreased heart weight,
decreased kidney weight,
decreased liver weight,
decreased locomotor activity,
decreased pituitary gland weight,
decreased prepulse inhibition,
decreased spleen weight,
delayed vaginal opening,
disproportionate dwarf,
increased brown adipose tissue amount,
increased circulating ghrelin level,
increased white adipose tissue amount,
preweaning lethality, incomplete penetrance,
reduced female fertility,
reduced fertility,
small adenohypophysis,
small heart,
small kidney,
small liver,
small spleen
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.