ltb Phenotypes

Phenotypes

XB-GENEPAGE-494845

Gene Symbol: ltb Gene Name: lymphotoxin beta

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: ltb assayed (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (37 sources): abnormal adaptive immunity, abnormal class switch recombination, abnormal colon morphology, abnormal humoral immune response, abnormal mesenteric lymph node morphology, abnormal spleen B cell follicle morphology, abnormal spleen follicular dendritic cell network, abnormal spleen germinal center morphology, abnormal spleen marginal zone morphology, abnormal spleen red pulp morphology, abnormal spleen white pulp morphology, absent Peyer's patches, absent axillary lymph nodes, absent brachial lymph nodes, absent cervical lymph nodes, absent follicular dendritic cells, absent germinal center B cells, absent inguinal lymph nodes, absent lymph nodes, absent mesenteric lymph nodes, absent peripheral lymph nodes, absent popliteal lymph nodes, absent spleen germinal center, absent spleen marginal zone, decreased IgG1 level, decreased IgG2a level, decreased marginal zone B cell number, decreased spleen germinal center number, decreased spleen germinal center size, decreased spleen white pulp amount, increased sensitivity to induced morbidity/mortality, increased sensitivity to xenobiotic induced morbidity/mortality, increased susceptibility to bacterial infection induced morbidity/mortality, increased susceptibility to parasitic infection, intermingled spleen red and white pulp, small Peyer's patches, spleen hyperplasia [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (37 sources): abnormal adaptive immunity, abnormal class switch recombination, abnormal colon morphology, abnormal humoral immune response, abnormal mesenteric lymph node morphology, abnormal spleen B cell follicle morphology, abnormal spleen follicular dendritic cell network, abnormal spleen germinal center morphology, abnormal spleen marginal zone morphology, abnormal spleen red pulp morphology, [+]