lrrk2 Phenotypes

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Phenotypes

Gene Literature (3)

Nucleotides (184)

Interactants (1810)

XB-GENEPAGE-5768571

Gene Symbol: lrrk2 Gene Name: leucine-rich repeat kinase 2

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
decreased length of anterior-posterior axis (2 sources), abnormal Wnt signaling pathway, planar cell polarity pathway (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: lrrk2 assayed (2 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + lrrk2 (2 sources), Xla Wt + lrrk2 (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (47 sources): Abnormal autonomic nervous system physiology, Agitation, Akinesia, Apathy, Bradykinesia, Cerebral cortical atrophy, Chronic constipation, Constipation, Dementia, Depression, Diplopia, Dysarthria, Dyskinesia, Dysphagia, Dystonia, Frequent falls, Gliosis, Hallucinations, Hypomimic face, Hyposmia, Impulsivity, Lewy bodies, Low frustration tolerance, Mask-like facies, Mental deterioration, Micrographia, Monotonic speech, Muscle spasm, Neuronal loss in central nervous system, Orthostatic hypotension due to autonomic dysfunction, Parkinsonism, Parkinsonism with favorable response to dopaminergic medication, Personality changes, Postural instability, Resting tremor, Rigidity, Schizophrenia, Short stepped shuffling gait, Shuffling gait, Sleep disturbance, Spastic/hyperactive bladder, Substantia nigra gliosis, Tremor, Urinary urgency, Visual hallucinations, Weak voice, Weight loss [+]
Mouse (55 sources): abnormal action potential, abnormal adrenal gland secretion, abnormal autophagy, abnormal axon extension, abnormal axon morphology, abnormal dendrite morphology, abnormal dendritic spine morphology, abnormal dopamine level, abnormal excitatory postsynaptic currents, abnormal hippocampal mossy fiber morphology, abnormal kidney morphology, abnormal lipid level, abnormal locomotor behavior, abnormal locomotor coordination, abnormal mitochondrial crista morphology, abnormal mitochondrial fission, abnormal neurite morphology, abnormal neurotransmitter uptake, abnormal proximal convoluted tubule morphology, abnormal response/metabolism to endogenous compounds, abnormal synaptic dopamine release, abnormal type II pneumocyte morphology, behavior/neurological phenotype, cardiovascular system phenotype, decreased dopamine level, decreased kidney weight, decreased neurotransmitter release, decreased physiological sensitivity to xenobiotic, dilated mitochondria, dilated renal tubules, enhanced coordination, granular kidney, impaired behavioral response to addictive substance, impaired behavioral response to xenobiotic, increased grooming behavior, increased kidney apoptosis, increased kidney weight, increased neuronal precursor cell number, increased neurotransmitter release, increased renal glomerulus apoptosis, increased renal tubule apoptosis, increased systemic arterial diastolic blood pressure, increased vertical activity, lipofuscinosis, long stride length, microgliosis, nervous system phenotype, no abnormal phenotype detected, preweaning lethality, incomplete penetrance, renal/urinary system phenotype, respiratory system phenotype, short stride length, skeleton phenotype, small kidney, tau protein deposits [+]
View all ortholog results at Monarch