| Monarch Ortholog Phenotypes
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Human (25 sources):
Abnormal brain FDG positron emission tomography,
Aggressive behavior,
Ataxia,
Atonic seizure,
Autistic behavior,
Bilateral tonic-clonic seizure,
Developmental regression,
Dysarthria,
EEG with abnormally slow frequencies,
EEG with spike-wave complexes (>3.5 Hz),
Epileptic encephalopathy,
Eyelid myoclonus,
Febrile seizure (within the age range of 3 months to 6 years),
Generalized myoclonic seizure,
Generalized myoclonic-atonic seizure,
Generalized non-motor (absence) seizure,
Global developmental delay,
Impulsivity,
Intellectual disability,
Mental deterioration,
Myoclonus,
Photosensitive tonic-clonic seizure,
Scoliosis,
Status epilepticus,
Tremor
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Mouse (24 sources):
abnormal GABA-mediated receptor currents,
abnormal behavioral response to xenobiotic,
abnormal bitter taste sensitivity,
abnormal conditioned taste aversion behavior,
abnormal contextual conditioning behavior,
abnormal inhibitory postsynaptic currents,
abnormal latent inhibition of conditioning behavior,
abnormal neurotransmitter secretion,
abnormal neurotransmitter uptake,
abnormal object recognition memory,
abnormal response to novel object,
abnormal spatial working memory,
alcohol preference,
decreased locomotor activity,
decreased prepulse inhibition,
enhanced behavioral response to xenobiotic,
hyperactivity elicited by ethanol administration,
impaired cued conditioning behavior,
increased alcohol consumption,
increased startle reflex,
nervous system phenotype,
no abnormal phenotype detected,
reduced sensorimotor gating,
saccharin preference
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.