| Monarch Ortholog Phenotypes
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Human (9 sources):
Abnormal circulating eicosanoid concentration,
Decreased serum thromboxane B2,
Duodenal ulcer,
Esophageal ulceration,
Gastric ulcer,
Impaired platelet aggregation,
Intestinal bleeding,
Iron deficiency anemia,
Jejunoileal ulceration
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Mouse (35 sources):
abnormal cytokine level,
abnormal macrophage physiology,
abnormal mast cell differentiation,
abnormal pulmonary vascular resistance,
abnormal renal tubule morphology,
abnormal response to injury,
abnormal response/metabolism to endogenous compounds,
cardiac hypertrophy,
cardiovascular system phenotype,
decreased airway resistance,
decreased cerebral infarct size,
decreased incidence of tumors by chemical induction,
decreased interferon-gamma secretion,
decreased litter size,
decreased physiological sensitivity to xenobiotic,
decreased susceptibility to dopaminergic neuron neurotoxicity,
decreased susceptibility to experimental autoimmune encephalomyelitis,
decreased susceptibility to ischemic brain injury,
decreased tumor necrosis factor secretion,
decreased urine osmolality,
enlarged myocardial fiber,
growth/size/body region phenotype,
immune system phenotype,
increased blood osmolality,
increased dopamine level,
increased heart weight,
increased left ventricle weight,
increased mast cell degranulation,
increased response of heart to induced stress,
increased skeletal muscle fiber diameter,
increased susceptibility to type I hypersensitivity reaction,
insulitis,
maternal effect,
parturition failure,
reduced female fertility
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.