Monarch Ortholog Phenotypes
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Mouse (46 sources):
abnormal T cell differentiation,
abnormal T follicular helper cell physiology,
abnormal effector T cell morphology,
abnormal germinal center B cell physiology,
abnormal intraepithelial T cell number,
abnormal lung development,
abnormal lymph node germinal center morphology,
abnormal small intestine crypts of Lieberkuhn morphology,
abnormal spleen B cell follicle morphology,
abnormal thymus development,
abnormal vertebral column morphology,
cecum inflammation,
crypts of Lieberkuhn abscesses,
curly tail,
decreased IgG1 level,
decreased IgG3 level,
decreased bone marrow cell number,
decreased immature B cell number,
enlarged lymph nodes,
granulomatous inflammation,
ileum inflammation,
immune system phenotype,
increased CD4-positive, alpha beta T cell number,
increased CD8-positive, alpha-beta T cell number,
increased IgG2b level,
increased T cell derived lymphoma incidence,
increased T cell proliferation,
increased T follicular helper cell number,
increased activated T cell number,
increased anti-double stranded DNA antibody level,
increased anti-nuclear antigen antibody level,
increased circulating tumor necrosis factor level,
increased lean body mass,
increased macrophage cell number,
increased regulatory T cell number,
increased spleen weight,
increased splenocyte number,
increased total body fat amount,
intestinal ulcer,
lymphoid hyperplasia,
neonatal lethality, complete penetrance,
perinatal lethality, complete penetrance,
preweaning lethality, incomplete penetrance,
primary atelectasis,
small intestinal inflammation,
spleen hyperplasia
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