Cerebral cortical atrophy, Cervical spinal cord atrophy, Cognitive impairment, Degeneration of the lateral corticospinal tracts, Dysarthria, Dysphagia, EMG: chronic denervation signs, Finger syndactyly, Gait ataxia, Gait disturbance, Generalized hyperreflexia, Hyperreflexia, Impaired pain sensation, Impaired vibration sensation in the lower limbs, Loss of speech, Lower limb hyperreflexia, Lower limb hypertonia, Lower limb muscle weakness, Lower limb pain, Lower limb spasticity, Memory impairment, Motor axonal neuropathy, Nasal speech, Nystagmus, Optic atrophy, Optic disc pallor, Paraplegia, Pes cavus, Progressive spastic paraparesis, Pseudobulbar signs, Ragged-red muscle fibers, Scoliosis, Slowed slurred speech, Somatic sensory dysfunction, Spastic dysarthria, Spastic gait, Spastic paraplegia, Spasticity, Specific learning disability, Supranuclear gaze palsy, Upper limb muscle weakness, Upper motor neuron dysfunction, Urinary bladder sphincter dysfunction, Urinary incontinence, Urinary urgency, Weakness due to upper motor neuron dysfunction