| Monarch Ortholog Phenotypes
|
Human (28 sources):
Abnormality of extrapyramidal motor function,
Aceruloplasminemia,
Anemia,
Ataxia,
Behavioral abnormality,
Blepharospasm,
Chorea,
Cogwheel rigidity,
Congestive heart failure,
Decreased circulating ceruloplasmin concentration,
Decreased serum iron,
Delayed speech and language development,
Dementia,
Depression,
Diabetes mellitus,
Dysarthria,
Elevated hepatic iron concentration,
Hypothyroidism,
Increased circulating ferritin concentration,
Involuntary movements,
Memory impairment,
Parkinsonism,
Refractory anemia,
Retinal degeneration,
Scanning speech,
Spasticity,
Torticollis,
Tremor
[+]
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Mouse (28 sources):
abnormal Kupffer cell morphology,
abnormal Purkinje cell morphology,
abnormal adipose tissue amount,
abnormal astrocyte morphology,
abnormal astrocyte physiology,
abnormal brain iron level,
abnormal cerebellar granule layer morphology,
abnormal circulating iron level,
abnormal fourth ventricle morphology,
abnormal hepatocyte morphology,
abnormal iron level,
abnormal lipid homeostasis,
abnormal liver copper level,
abnormal locomotor activation,
abnormal locomotor behavior,
abnormal response to injury,
abnormal retina inner nuclear layer morphology,
abnormal sleep behavior,
decreased circulating ceruloplasmin level,
decreased circulating iron level,
decreased motor neuron number,
hematopoietic system phenotype,
hemochromatosis,
increased cellular sensitivity to hydrogen peroxide,
increased circulating ferritin level,
increased circulating unsaturated transferrin level,
increased spleen iron level,
neuron degeneration
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.