Monarch Ortholog Phenotypes
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Human (32 sources):
Agammaglobulinemia,
Arthritis,
Bronchiectasis,
Cellulitis,
Chronic otitis media,
Conjunctivitis,
Cough,
Dehydration,
Diarrhea,
Epicanthus,
Failure to thrive,
Fatigue,
Fever,
Hepatitis,
High palate,
Hypertelorism,
Immunodeficiency,
Malabsorption,
Meningitis,
Neutropenia,
Osteomyelitis,
Recurrent bacterial infections,
Recurrent bronchitis,
Recurrent infections,
Recurrent otitis media,
Recurrent respiratory infections,
Recurrent skin infections,
Sepsis,
Sinusitis,
Skin rash,
Verrucae,
obsolete External ear malformation
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Mouse (39 sources):
abnormal B cell activation,
abnormal T cell differentiation,
abnormal class switch recombination,
abnormal humoral immune response,
abnormal metallophilic macrophage morphology,
abnormal mitosis,
abnormal spleen marginal zone macrophage morphology,
abnormal spleen red pulp morphology,
absent immature B cells,
absent mature B cells,
absent pre-B cells,
arrested B cell differentiation,
decreased B cell proliferation,
decreased B-1 B cell number,
decreased B-1a cell number,
decreased IgG1 level,
decreased IgG2b level,
decreased IgG2c level,
decreased IgG3 level,
decreased double-positive T cell number,
decreased follicular B cell number,
decreased immature B cell number,
decreased marginal zone B cell number,
decreased mature B cell number,
decreased pre-B cell number,
hematopoietic system phenotype,
immune system phenotype,
impaired humoral immune response,
increased IgG2b level,
increased IgG2c level,
increased anti-single stranded DNA antibody level,
increased immature B cell number,
increased pre-B cell number,
increased pro-B cell number,
increased transitional stage B cell number,
increased transitional stage T1 B cell number,
increased transitional stage T2 B cell number,
increased transitional stage T3 B cell number,
no abnormal phenotype detected
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View all ortholog results at Monarch
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