nbn Phenotypes

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Phenotypes

Gene Literature (42)

Nucleotides (122)

Interactants (244)

XB-GENEPAGE-943035

Gene Symbol: nbn Gene Name: nibrin

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (86 sources): Abnormal eyelid morphology, Abnormal hair morphology, Abnormal hair quantity, Abnormality of chromosome stability, Abnormality of neuronal migration, Abnormality of the face, Abnormality of the musculature, Acute leukemia, Acute lymphoblastic leukemia, Anal atresia, Anal stenosis, Anemia, Anorectal anomaly, Aplastic anemia, Attention deficit hyperactivity disorder, Autoimmune hemolytic anemia, B lymphocytopenia, B-cell lymphoma, Bone marrow hypocellularity, Bronchiectasis, Cachexia, Cafe-au-lait spot, Choanal atresia, Chronic diarrhea, Cleft palate, Cleft upper lip, Convex nasal ridge, Cutaneous photosensitivity, Deep philtrum, Depressed nasal bridge, Diarrhea, Dysgammaglobulinemia, Ecchymosis, Epistaxis, Freckling, Gingival bleeding, Glioma, Hearing abnormality, Hemolytic anemia, Hydronephrosis, Hyperactivity, Intellectual disability, Intrauterine growth retardation, Long nose, Low anterior hairline, Lymphoma, Macrotia, Malar prominence, Mastoiditis, Medulloblastoma, Mental deterioration, Microcephaly, Micrognathia, Muscle weakness, Neoplasm, Neurodegeneration, Neutropenia, Non-midline cleft of the upper lip, Otitis media, Pancytopenia, Pollakisuria, Premature ovarian insufficiency, Progressive vitiligo, Prominent nasal bridge, Prominent nose, Recurrent bronchitis, Recurrent infection of the gastrointestinal tract, Recurrent infections, Recurrent pneumonia, Recurrent respiratory infections, Recurrent sinopulmonary infections, Recurrent urinary tract infections, Respiratory insufficiency, Reticulocytopenia, Retinal hemorrhage, Retrognathia, Rhabdomyosarcoma, Short neck, Short stature, Sinusitis, Skeletal muscle atrophy, Sloping forehead, T lymphocytopenia, T-cell lymphoma, Thrombocytopenia, Upslanted palpebral fissure [+]
Mouse (61 sources): abnormal astrocyte morphology, abnormal cell cycle checkpoint function, abnormal cell-mediated immunity, abnormal cerebellar Purkinje cell layer, abnormal cerebellar granule layer morphology, abnormal cerebellum external granule cell layer morphology, abnormal extraembryonic tissue morphology, abnormal inner cell mass apoptosis, abnormal involuntary movement, abnormal neuron differentiation, abnormal trophectoderm morphology, absent cerebellar foliation, absent embryonic epiblast, absent extraembryonic ectoderm, absent inner cell mass proliferation, absent oocytes, absent ovarian follicles, absent proamniotic cavity, cellular phenotype, chromosomal instability, decreased B cell proliferation, decreased CD4-positive, alpha beta T cell number, decreased IgG1 level, decreased IgG2a level, decreased IgG2b level, decreased IgG3 level, decreased brain weight, decreased cellular sensitivity to ionizing radiation, decreased embryo size, decreased fibroblast proliferation, decreased inner cell mass proliferation, decreased mature B cell number, decreased oocyte number, decreased pre-B cell number, decreased tumor latency, disorganized embryonic tissue, embryonic lethality between implantation and somite formation, complete penetrance, immune system phenotype, impaired balance, increased B cell derived lymphoma incidence, increased Leydig cell tumor incidence, increased T cell derived lymphoma incidence, increased apoptosis, increased cellular sensitivity to gamma-irradiation, increased gonad tumor incidence, increased incidence of tumors by ionizing radiation induction, increased liver adenocarcinoma incidence, increased liver adenoma incidence, increased lymphoma incidence, increased mammary adenocarcinoma incidence, increased mortality induced by gamma-irradiation, increased prostate intraepithelial neoplasia incidence, increased thyroid adenoma incidence, increased tumor incidence, inner cell mass degeneration, nervous system phenotype, ovary degeneration, prenatal lethality, complete penetrance, reproductive system phenotype, small cerebellum, small ovary [+]
View all ortholog results at Monarch