serpine2 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-947566

Gene Symbol: serpine2 Gene Name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
decreased size of the head (2 sources), abnormal branchial basket morphology (1 source), abnormal cartilage tissue (1 source), abnormal cartilage tissue morphology (1 source), abnormal cell migration in neural crest (1 source), abnormal ethmoid region (1 source), abnormally decreased number of pigment cell (1 source), absent dorsal fin (1 source), decreased size of the Meckel's cartilage (1 source), decreased size of the ceratohyal (1 source), decreased size of the head region (1 source), decreased size of the main body axis (1 source), decreased size of the palatoquadrate (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

decreased size of the head (2 sources), abnormal branchial basket morphology (1 source), abnormal cartilage tissue (1 source), abnormal cartilage tissue morphology (1 source), abnormal cell migration in neural crest (1 source), abnormal ethmoid region (1 source), abnormally decreased number of pigment cell (1 source), absent dorsal fin (1 source), decreased size of the Meckel's cartilage (1 source), decreased size of the ceratohyal (1 source), decreased size of the head region (1 source), decreased size of the main body axis (1 source), decreased size of the palatoquadrate (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: serpine2 manipulated (4 sources)
Computed annotations: serpine2 assayed (4 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + serpine2 MO (6 sources), Xla Wt + serpine2 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (24 sources): abnormal acute phase protein level, abnormal astrocyte morphology, abnormal cerebellar granule layer morphology, abnormal cerebellum external granule cell layer morphology, abnormal copulatory plug formation, abnormal excitatory postsynaptic currents, abnormal excitatory postsynaptic potential, abnormal motor capabilities/coordination/movement, abnormal peripheral nervous system regeneration, abnormal prostate gland physiology, abnormal response to injury, abnormal sciatic nerve morphology, abnormal seminal vesicle epithelium morphology, abnormal seminal vesicle fluid composition, abnormal seminal vesicle morphology, abnormal sensory capabilities/reflexes/nociception, decreased Schwann cell number, dilated seminal vesicles, increased cell proliferation, increased susceptibility to pharmacologically induced seizures, reduced NMDA receptor mediated synaptic activity in barrel cortex, reduced long term potentiation, reduced male fertility, reproductive system phenotype [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (24 sources): abnormal acute phase protein level, abnormal astrocyte morphology, abnormal cerebellar granule layer morphology, abnormal cerebellum external granule cell layer morphology, abnormal copulatory plug formation, abnormal excitatory postsynaptic currents, abnormal excitatory postsynaptic potential, abnormal motor capabilities/coordination/movement, abnormal peripheral nervous system regeneration, abnormal prostate gland physiology, [+]