shank2 Phenotypes

Phenotypes

XB-GENEPAGE-984533

Gene Symbol: shank2 Gene Name: SH3 and multiple ankyrin repeat domains 2

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: shank2 assayed (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (32 sources): abnormal cerebellar molecular layer, abnormal dendritic spine morphology, abnormal excitatory postsynaptic potential, abnormal excitatory synapse morphology, abnormal learning/memory/conditioning, abnormal locomotor behavior, abnormal miniature excitatory postsynaptic currents, abnormal motor capabilities/coordination/movement, abnormal nest building behavior, abnormal pup retrieval, abnormal response to novelty, abnormal sexual interaction, abnormal social investigation, abnormal spatial learning, abnormal vocalization, abnormal voluntary movement, behavior/neurological phenotype, decreased erythrocyte cell number, decreased hematocrit, decreased liver weight, decreased vocalization, enhanced long term potentiation, impaired righting response, improved righting response, increased anxiety-related response, increased grooming behavior, increased thigmotaxis, limb grasping, nervous system phenotype, postnatal lethality, incomplete penetrance, reduced long term depression, reduced long term potentiation [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (32 sources): abnormal cerebellar molecular layer, abnormal dendritic spine morphology, abnormal excitatory postsynaptic potential, abnormal excitatory synapse morphology, abnormal learning/memory/conditioning, abnormal locomotor behavior, abnormal miniature excitatory postsynaptic currents, abnormal motor capabilities/coordination/movement, abnormal nest building behavior, abnormal pup retrieval, [+]