wrn Phenotypes

Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Phenotypes

Gene Literature (22)

Nucleotides (129)

Interactants (62)

XB-GENEPAGE-992874

Gene Symbol: wrn Gene Name: Werner syndrome, RecQ helicase-like

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (67 sources): Abnormal cerebral vascular morphology, Abnormal hair morphology, Abnormal hair whorl, Abnormal testis morphology, Abnormal thorax morphology, Abnormality of retinal pigmentation, Abnormality of the voice, Acral lentiginous melanoma, Aplasia/Hypoplasia of the skin, Aplasia/Hypoplasia of the testes, Atherosclerosis, Breast carcinoma, Cataract, Chondrocalcinosis, Congestive heart failure, Convex nasal ridge, Cough, Cutaneous melanoma, Decreased fertility, Diabetes mellitus, Gastrointestinal carcinoma, Hyperkeratosis, Hypertension, Hypogonadism, Increased bone mineral density, Insulin resistance, Joint stiffness, Lack of skin elasticity, Laryngomalacia, Lipoatrophy, Lipodystrophy, Melanoma, Meningioma, Miscarriage, Myocardial infarction, Narrow face, Neoplasm, Neoplasm of the lung, Neoplasm of the oral cavity, Neoplasm of the small intestine, Osteoporosis, Osteosarcoma, Ovarian neoplasm, Pili torti, Premature arteriosclerosis, Premature graying of hair, Prematurely aged appearance, Progeroid facial appearance, Pulmonary artery stenosis, Renal neoplasm, Retinal degeneration, Rocker bottom foot, Sarcoma, Scleroderma, Secondary amenorrhea, Short stature, Skeletal muscle atrophy, Skin ulcer, Slender build, Small hand, Sparse scalp hair, Squamous cell carcinoma, Subcutaneous calcification, Telangiectasia of the skin, Thyroid carcinoma, Type II diabetes mellitus, White forelock [+]
Mouse (17 sources): abnormal cardiovascular development, abnormal circulating hyaluronic acid level, abnormal thrombosis, cardiac interstitial fibrosis, decreased bone volume, decreased systemic arterial diastolic blood pressure, heart inflammation, increased abdominal adipose tissue amount, increased cellular sensitivity to oxidative stress, increased inguinal fat pad weight, increased left ventricle systolic pressure, increased osteoclast cell number, increased retroperitoneal fat pad weight, increased susceptibility to age related obesity, increased tumor incidence, oxidative stress, preweaning lethality, incomplete penetrance [+]
View all ortholog results at Monarch