| Monarch Ortholog Phenotypes
|
Human (36 sources):
Abnormal caudate nucleus morphology,
Abnormal corpus striatum morphology,
Abnormal globus pallidus morphology,
Abnormality of thalamus morphology,
Bradykinesia,
Cerebellar hypoplasia,
Cerebral hypoplasia,
Cognitive impairment,
Compulsive behaviors,
Depression,
Developmental regression,
Difficulty walking,
Distal amyotrophy,
Dysarthria,
Dystonia,
Eye of the tiger anomaly of globus pallidus,
Flexion contracture,
Gait disturbance,
Global developmental delay,
Hypoplasia of the brainstem,
Hypoplasia of the corpus callosum,
Hyporeflexia,
Mental deterioration,
Microcephaly,
Micrognathia,
Motor axonal neuropathy,
Neurodegeneration,
Oromandibular dystonia,
Parkinsonism,
Peripheral axonal neuropathy,
Pes cavus,
Rigidity,
Sloping forehead,
Spastic paraparesis,
Spastic tetraplegia,
obsolete Toe walking
[+]
|
|
Mouse (9 sources):
abnormal calcium level,
abnormal magnesium level,
abnormal mitochondrial physiology,
abnormal tail movements,
decreased brain weight,
impaired righting response,
nervous system phenotype,
positive geotaxis,
premature death
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.