abnormal renal glomerulus morphology, absent amniotic folds, decreased CD4-positive, alpha beta T cell number, decreased T cell proliferation, decreased circulating interleukin-10 level, decreased embryo size, decreased myocardial infarct size, decreased primordial ovarian follicle number, decreased red blood cell distribution width, decreased susceptibility to experimental autoimmune encephalomyelitis, embryonic growth arrest, embryonic lethality between implantation and somite formation, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, immune system phenotype, impaired autophagy, increased B cell derived lymphoma incidence, increased CD4-positive NK T cell number, increased T cell apoptosis, increased anti-double stranded DNA antibody level, increased anti-nuclear antigen antibody level, increased autoantibody level, increased circulating creatinine level, increased circulating interleukin-1 beta level, increased circulating interleukin-12b level, increased circulating interleukin-6 level, increased embryonic tissue cell apoptosis, increased follicular lymphoma incidence, increased hepatocellular carcinoma incidence, increased histiocytic sarcoma incidence, increased lung adenoma incidence, increased lung carcinoma incidence, increased lymphoma incidence, increased malignant tumor incidence, increased mammary gland tumor incidence, increased memory-marker CD4-positive NK T cell number, increased myocardial infarct size, increased neutrophil cell number, increased plasmacytoma incidence, increased spleen germinal center number, increased spleen germinal center size, increased startle reflex, increased susceptibility to systemic lupus erythematosus, increased tumor incidence, no abnormal phenotype detected, premature death, prenatal lethality, complete penetrance, preweaning lethality, complete penetrance, small ovary