BMP2, nucleic acid
BMP2, nucleic acid
Cloned independantly by a number of people. The one used here was cloned by Nishimatsu, et al. 1992. The characterization of expression pattern shown here was performed by Jerry Thomsen and Ali Hemmati-Brivanlou.
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A. An anterior view of a stage 18 neurula showing an anterior-ventral patch of BMP-2 expression indicated by the arrow. The anterior neural folds at the top of the embryo also express BMP-2. B. Cleared stage 18 embryo showing the patch of ventral anterior BMP-2 expression. The embryo is oriented with the anterior at right, dorsal side up. C. Staining in the neural folds of a stage 18 embryo (left) and stage 22 embryo (right) is shown.
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D. Stage 24 tadpole showing localized head, dorsal fin, somite and ventral-anterior expression of BMP-2; posterior left, anterior right. E. Stage 28 tailbud embryo indicating the localized expression of BMP-2 in the head, pharyngeal pouches, heart, somites and fin (f). F. Expression of BMP-2 in the heart of a stage 36 tadpole.
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I. Head of a stage 36 tadpole viewed from the side. BMP-2 is localized to the pineal gland (arrow labelled p), forebrain (stained patch just below the pineal), nasal placodes (largest patch of staining, just below forebrain stain), tissue adjacent to the cement gland, and near the heart (most ventral patch of staining). Head of a stage 36 tadpole viewed from the side. BMP-2 is localized to the pineal gland (small top patch of cells), forebrain (second patch from the top), nasal placodes (largest patch of staining), posterior cement gland, and heart (same embryo as depicted in panel H.
J. Face-on view of a stage 36 head showing the bilaterally-symetric expression of BMP-2 in the same structures as in panel I.
K. Close-up of the head shown in panel J to emphasize BMP-2 expression in the ventricular layer of the brain (top pair of spots), nasal placodes (middle pair of spots) and at the cement gland (bottom pair of spots) Signals from the heart are cut off at the bottom border of the panel.
L. Expression of BMP-2 at the base of the cement gland at stage 36.
A composite of all these figures and more!
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- Original Reference; Nishimatsu, S, Suzuki A, Shoda A, Murakami, K, and Ueno N (1992) Genes for bone morphogenetic proteins are differentially transcribed in early
amphibian embryos. Biochem. Biophys. Res. Com. 186(3): 1487-1495.
- Recent application reference; A. Hemmatti-Brivanlou and G.H. Thomsen (1995). Ventral mesodermal patterning in Xenopus embryos: expression patterns and actvities of
BMP-2 and BMP-4. Devl. Genet 17. (in press).
- Data base accession number; Genbank X63424
- Download DNA sequence
- Plasmid name; pGEM7-BMP2.Xba
- Diagnostic cut (to check identity of plasmid);
- For sense RNA transcripts cut with and transcribe with
- For antisense RNA transcripts cut with and transcribe with
- Available from; Ali or Jerry
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