Pax-3; neural plate
Pax-3, nucleic acid.
A paired-type homeobox gene that is specifically expressed in the dorsal and posterior neural tube. Cloned by Espeseth et al., 1995. These images are from Bang et al., 1997.
(A) Dorsovegetal and, (B) lateral view at stage 11.5 showing that Pax-3 is expressed in distinct lateral domains of the presumptive neural plate. (C) Dorsal view at stage 12 showing the renement of Pax-3 expression to lateral domains of the neural plate during convergence and extension. (D) Transverse paraffin section of a stage 16 embryo, showing that Pax-3 expression is restricted to the lateral neural plate (arrow), overlying somitic and
lateral plate mesoderm. (E) Dorsoanterior view of a stage 18 embryo
hybridized with Pax-3 (light blue, rostral extent indicated by a white
arrow) and en-2 (purple, indicated by a black arrow) showing that
Pax-3 expression extends just rostral to the mb-hb boundary. n,
notochord; s, somite. Scale bars, (A-C, E) 200 m; (D) 100 m.
Images are from Bang et al., 1997.
Figures and text Copyright © 1997, Company of Biologists.
- Reference; Anne G. Bang, Nancy Papalopulu, Chris Kintner and Martyn D. Goulding. Expression of Pax-3 is initiated in the early neural plate by posteriorizing
signals produced by the organizer and by posterior non-axial mesoderm. Development 124, 2075-2085 (1997).
Espeseth, A., Johnson, E. and Kintner, C. (1995). Xenopus F-cadherin, a
novel member of the cadherin family of cell adhesion molecules, is expressed
at boundaries in the neural tube. Mol. Cell Neurosci. 6, 199-211.
- Nucleotide and protein sequence
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