Chordin; dorsal lip
Chordin, nucleic acid.
(last modified August 11, 1995)
Cloned by Sasai et al., 1994. Expressed in dorsal mesoderm. Probably the vertebrate homolog of Drosophila sog, short gastrulation (Francois et al., 1994). Has dorsalizing properties.
Stage 10.25 vegetal view. Dorsal is up.
. Stage 10.5 gastrula, vegetal view.
. Stage 13 early neurula. Dorsal view. Anterior is up.
Link to the DeRobertis lab Chordin web page
- Reference; Sasai Y. Lu B. Steinbeisser H. Geissert D. Gont LK. De Robertis EM. (1994) Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes. Cell. 79 (5):779-90
- Clone name: bluescript chdF11
- vector; bluescript SK-
- insert; full length (3.8kb) chd cDNA as XhoI/EcoRI fragment.
- Download sequence
- for sense; cut with XhoI transcribe with T3
- for antisense; cut with EcoRI and transcribe with T7
- available from; E.DeRobertis, Dept. of Biological Chemistry, UCLA, 10833 Le Conte Av. Los Angeles CA 90024 USA.
- also avaiable in p64T derived translation vector for microinjection studies.
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Stage 10.25 vegetal view. Dorsal is up.
. Stage 10.5 gastrula, vegetal view. 
. Stage 13 early neurula. Dorsal view. Anterior is up.
