Xslu (Slug); neural crest
Xslu (Slug), nucleic acid
Cloned by Roberto Mayor, Richard Morgan and Mike Sargent at the NIMR, Mill Hill. Slug is related to Snail, another zinc finger protein expressed in presumtive crest. Slug is found in both pre- and post-migratory cranial and trunk neural crest (stage 12+), and in the lateral plate (stage 17+).
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A. Stage 12, dorsal view. b = blastopore, c=presumptive crest.
B. Stage 14, dorsal view. d= deep layer of ectoderm, s=superficial. weal expression in prospective trunk crest.
C. Stage 16, dorsal view.
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D. Stage 18. m=madibular h=hyoid, b=branchial crest aggregates.e=eye, t=trunk crest
E. Stage 22. Note crest surrounding the eye.
F. Stage 25. lp=lateral plate (not in pronephros, p).
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G.Transverse section of Xslu stained embryo, stage 18.
These images are all Copyright ©, Company of Biologists 1995.
- Reference; Mayor, R., Morgan, R. and Sargent, M.G. (1995) Induction of the prospective neural crest of Xenopus. Development 121, 767-777.
Nieto, M.A., Sargent, M.G., Wilkinson, D.G. and Cooke, J. (1994). Control of cell behaviour during development by Slug, a zinc-finger gene. Science 264, 835-839. (Chick)
- EMBL accession number X80269. Download.
- Plasmid; Xslu cDNA in pSP72
- Probes; Region from 968-1701 used as probe as it has minimal homology to Snail.
- Available from; M.Sargent
For an excellent reference on Xenopus crest development using SEM see Sadaghiani and Thiebaud (1987) Devl.Biol. 124; 91-110.
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