Announcing the availability of an Antisense Facility for Xenopus researchers

Antisense Facility for Xenopus researchers

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Please note address change of antisense facility!

For those people who are interested in loss of function studies on maternal Xenopus genes but who need advice and help on antisense and host-transfer techniques to target their gene of interest, there is now a small NIH-funded teaching facility available. From July 1999, the Heasman/Wylie laboratory at the Cincinnati Children's Hospital Medical Center will be able to offer individual hands-on instruction of the antisense depletion and host-transfer techniques. Teaching assistance will range from advice and encouragement, to week-long visits to the core facility to learn and carry out the antisense depletion and host-transfer techniques. Minorities and females are encouraged to apply. Financial assistance for travel and lab expenses will be available from a small fund for needy cases. Contact Janet.Heasman@chmcc.org for further information.

Antisense News

Those interested in studying the function of maternal or early zygotic genes may like to try a different antisense approach. Morpholino oligos (marketed by Gene Tools) are less toxic than phosphorothioates, and can be injected into fertilized eggs. In recent experiments targetting maternal beta catenin, a morpholino caused a ventralized phenotype when injected at the two cell stage. It also continued to affect beta catenin protein levels through the neurula stage. For more information contact:

Janet.Heasman@chmcc.org

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