Search Lines and Strains
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| Line Name | Species | Mutated Gene(s) | Description | Availability |
| Xla.trilemNXR | X. laevis | tril.L tril.S | CRISPR knockout of tril (LR4 interactor with leucine-rich repeats). Co-injected for both L and S. Ge... | NXR |
| Xla.tracemHorb | X. laevis | trac.S | X. laevis CRISPR line targeting trac.S (T cell receptor alpha constant), a gene associated with immu... | NXR |
| Xla.thrbem3NXR | X. laevis | thrb.L | Double CRISPR mutant line of thrb (thyroid hormone receptor, beta ) with animals carrying a 8bp dele... | |
| Xla.thrbem2NXR | X. laevis | thrb.S | CRISPR knockout of thrb.S thyroid hormone receptor, beta S homolog). germline transmission confirmed... | |
| Xla.thrbem1NXR | X. laevis | thrb.L | CRISPR knockout of thrb.L thyroid hormone receptor, beta L homolog). germline transmission confirmed... | |
| Xla.tcf3emNXR | X. laevis | tcf3.L | X. laevis CRISPR line targeting tcf3.L (transcription factor 3). Line in development. Contact NXR f... | NXR |
| Xla.tcf3em2NXR | X. laevis | CRISPR knockout of tcf3.S ( transcription factor 3). Germ line transmission not yet confirmed. Cont... | ||
| Xla.tbx21emNXR | X. laevis | tbx21.L tbx21.S | double CRISPR KO line targeting tbx21.L and tbx21.S in X. laevis. germ line transmission snd mutatio... | NXR |
| Xla.tap2emNXR | X. laevis | tap2.L tap2.S | X. laevis CRISPR line targeting tap2 (transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), a... | NXR |
| Xla.tap1emNXR | X. laevis | tap1.L | X. laevis CRISPR line targeting tap1 (transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), a... | NXR |
| Xla.sox10emHorb | X. laevis | sox10.L sox10.S | Probable double CRISPR knockout of sox10 (SRY-box 10). Confirmed germline transmission in sox10.L (W... | NXR |
| Xla.sobpemNXR | X. tropicalis | sobp | CRISPR knockout of sobp (sine oculis binding protein homolog ), a gene associated with MRAMS, an in... | |
| Xla.slc45a2em2NXR | X. laevis | slc45a2.L | CRISPR knockout of slc45a2 (solute carrier family 45 member 2 ). Screened for germline transmission.... | |
| Xla.slc16a2emHorb | X. laevis | slc16a2.L slc16a2.S | Double CRISPR knockout of slc16a2 (solute carrier family 16, member 2 (thyroid hormone transporter))... | NXR |
| Xla.scanwemNXR | X. laevis | CRISPR knock out of the male sex determining gene, scan-w. Animals carry a 20bp deletion in scanw. ... | NXR | |
| Xla.rykemNXR | X. laevis | ryk.S | CRISPR knockout of ryk.S (receptor like tyrosine kinase S homeolog). Germline transmission not yet c... | NXR |
| Xla.runx1em(GFP)EXRC | X. laevis | runx1.L | CRISPR-Cas9 mediated insertion of IRES-GFP sequence into the 3'-UTR of runx1 gene, | |
| Xla.rag2emNXR | X. laevis | rag2.L | CRISPR knockout of rag2 (recombination activating 2). Germ line transmission confirmed. Animals carr... | NXR |
| Xla.prph2emHorb | X. laevis | prph2.L prph2.S | X. laevis CRISPR knockout line of prph2 (peripherin 2 (retinal degeneration, slow)). Mutant line gen... | |
| Xla.prkdcem2NXR | X. laevis | prkdc.L | CRISPR KO of prkdc (protein kinase, DNA-activated, catalytic subunit ). Germ line transmission confi... | NXR |
| Xla.prkdcem1NXR | X. laevis | prkdc.L | CRISPR KO of prkdc (protein kinase, DNA-activated, catalytic subunit ). Germ line transmission confi... | NXR |
| Xla.prickle1emHorb | X. laevis | prickle1.L prickle1.S | CRISPR knockout of prickle1(prickle planar cell polarity protein 1). Confirmed germ line transmissio... | NXR |
| Xla.ppp2r2aemHorb | X. laevis | ppp2r2a.L | CRISPR knockout of ppp2r2a (protein phosphatase 2 regulatory subunit B, alpha ). Current mosaic foun... | NXR |
| Xla.pkhd1emHorb | X. laevis | pkhd1.L | CRISPR knockout of pkhd1 (PKHD1, fibrocystin/polyductin), Germ line transmission confirmed. Animals ... | |
| Xla.pkhd1em3Horb | X. laevis | pkhd1.L | 3rd of 3 X. laevis CRISPR lines for pkhd1 (ciliary IPT domain containing fibrocystin/polyductin) gen... | NXR |
| Xla.pkhd1em2Horb | X. laevis | pkhd1.L | CRISPR knockout of pkhd1 (PKHD1, fibrocystin/polyductin), Germ line transmission confirmed. Animals ... | NXR |
| Xla.pkd2emHorb | X. laevis | pkd2.L | CRISPR knockout of pkd2 (polycystin 2, transient receptor potential cation channel ). Confirmed germ... | |
| Xla.pkd1em3Horb | X. laevis | pkd1.L | CRISPR knockout of pkd1 (polycystin 1, transient receptor potential channel interacting). Germ line ... | |
| Xla.pkd1em2Horb | X. laevis | pkd1.L | CRISPR knockout of pkd1 (polycystin 1, transient receptor potential channel interacting). Germ line ... | NXR |
| Xla.pkd1em1Horb | X. laevis | pkd1.L | CRISPR knockout of pkd1 (polycystin 1, transient receptor potential channel interacting). Germ line... | |
| Xla.pcntemHorb | X. laevis | pcnt.L | CRISPR knockout of pcnt (pericentrin ). Confirmed germline transmission. Custom mutant generated by ... | |
| Xla.pax7emHorb | X. laevis | pax7.L | CRISPR knockout of pax7 (paired box ). Germ line transmission confirmed. Animals carry a 4bp 9 bp o... | NXR |
| Xla.pax7em3Horb | X. laevis | pax7.L pax7.S | 3rd Xlaevis pax7 mutant line at the NXR. CRISPR knockout of pax7 (paired box 7). Germ line transmiss... | NXR |
| Xla.pax7em2Horb | X. laevis | pax7.L pax7.S | CRISPR knockout of pax7 (paired box ). Germ line transmission confirmed. Animals carry a -22bp dele... | NXR |
| Xla.pax3emHorb | X. laevis | pax3.L | CRISPR knockout of pax3 (paired box 3). Germ line transmission confirmed. animals carry a 11bp delet... | |
| Xla.olig3emHorb | X. laevis | olig3.S | CRISPR knockout of olig3 (oligodendrocyte transcription factor 3) ( olig3.S in Xlaevis). Current mos... | |
| Xla.olig2emHorb | X. laevis | olig2.L | CRISPR knockout of olig2 (oligodendrocyte lineage transcription factor 2) in X. laevis. KOs both oli... | |
| Xla.npffr1.1emEXRC | X. laevis | npffr1.1.L | Crispr-Cas9 mutation in the npffr1.1 gene (neuropeptide FF receptor 1, gene 1 ). | |
| Xla.notch4emHorb | X. laevis | notch4.S | TALEN knockout of notch4 in X. laevis. THIS LINE is no longer available from the NXR | |
| Xla.myogemNXR | X. laevis | myog.L | CRISPR knockout of myog (myogenin) in Xlaevis. Germ line transmission not yet confirmed. F0 founders... | |
| Xla.myod1emNXR | X. laevis | myod1.L | CRISPR knockout of myod1 (myogenic differentiation 1) in X laevis. Germ line transmission not yet co... | |
| Xla.myod1em2NXR | X. laevis | myod1.L | CRISPR knockout of myod1 (myogenic differentiation 1) in X laevis. Germ line transmission not yet co... | |
| Xla.myf6emNXR | X. laevis | myf6.L | TALENS knockout of myf6 (myogenic factor 6) in X. laevis. Germ line transmission confirmed. Contact... | |
| Xla.myf5emNXR | X. laevis | myf5.L | CRISPR knockout of myf5 (myogenic factor 5). Germ line transmission not yet confirmed. F0 founders. ... | |
| Xla.mitfemHorb | X. laevis | mitf.L | CRISPR knockout of mitf (melanocyte inducing transcription factor) Germ line transmission confirmed.... | |
| Xla.mcidasemHorb | X. laevis | mcidas.L | CRISPR knockout of mcidas (multiciliate differentiation and DNA synthesis associated cell cycle prot... | |
| Xla.kcptmFlc | X. laevis | kcp.L | One-cell stage Xenopus Xla.Tg(Cardiac-actin:GFP)Mohun embryos were microinjected with 1 ng TALEN mRN... | |
| Xla.il2rgem2NXR | X. laevis | CRISPR knockout of il2rg (interleukin 2 receptor subunit gamma). Germ line transmission confirmed. A... | ||
| Xla.il2rgem1NXR | X. laevis | il2rg.L | CRISPR knockout of il2rg (interleukin 2 receptor subunit gamma). Germ line transmission confirmed. ... | |
| Xla.hps4m | X. laevis | hps4.L | This periodic albino mutant of Xenopus laevis is a recessive mutant. Fukazawa et al 2020 showed that... |
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