Papers associated with kcnh2

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	The antipsychotic drug chlorpromazine inhibits HERG potassium channels., Thomas D, Wu K, Kathöfer S, Katus HA, Schoels W, Kiehn J, Karle CA., Br J Pharmacol. June 1, 2003; 139 (3): 567-74.
	Negative charges in the transmembrane domains of the HERG K channel are involved in the activation- and deactivation-gating processes., Liu J, Zhang M, Jiang M, Tseng GN., J Gen Physiol. June 1, 2003; 121 (6): 599-614.
	Regulation of HERG potassium channel activation by protein kinase C independent of direct phosphorylation of the channel protein., Thomas D, Zhang W, Wu K, Wimmer AB, Gut B, Wendt-Nordahl G, Kathöfer S, Kreye VA, Katus HA, Schoels W, Kiehn J, Karle CA., Cardiovasc Res. July 1, 2003; 59 (1): 14-26.
	Inhibition of cloned HERG potassium channels by the antiestrogen tamoxifen., Thomas D, Gut B, Karsai S, Wimmer AB, Wu K, Wendt-Nordahl G, Zhang W, Kathöfer S, Schoels W, Katus HA, Kiehn J, Karle CA., Naunyn Schmiedebergs Arch Pharmacol. July 1, 2003; 368 (1): 41-8.
	Gating currents associated with intramembrane charge displacement in HERG potassium channels., Piper DR, Varghese A, Sanguinetti MC, Tristani-Firouzi M., Proc Natl Acad Sci U S A. September 2, 2003; 100 (18): 10534-9.
	Differential recovery of action potential duration and HERG currents from the effects of two methanesulfonamide class III antiarrhythmic agents, KCB-328 and dofetilide., Lee K, Park JB, Jeon BH, Kim KJ, Ryu PD, Kwon LS, Kim HY., J Cardiovasc Pharmacol. November 1, 2003; 42 (5): 648-55.
	Drug binding to aromatic residues in the HERG channel pore cavity as possible explanation for acquired Long QT syndrome by antiparkinsonian drug budipine., Scholz EP, Zitron E, Kiesecker C, Lueck S, Kathöfer S, Thomas D, Weretka S, Peth S, Kreye VA, Schoels W, Katus HA, Kiehn J, Karle CA., Naunyn Schmiedebergs Arch Pharmacol. November 1, 2003; 368 (5): 404-14.
	Acute effects of dronedarone on both components of the cardiac delayed rectifier K+ current, HERG and KvLQT1/minK potassium channels., Thomas D, Kathofer S, Zhang W, Wu K, Wimmer AB, Zitron E, Kreye VA, Katus HA, Schoels W, Karle CA, Kiehn J., Br J Pharmacol. November 1, 2003; 140 (5): 996-1002.
	Physicochemical features of the HERG channel drug binding site., Fernandez D, Ghanta A, Kauffman GW, Sanguinetti MC., J Biol Chem. March 12, 2004; 279 (11): 10120-7.
	BmTx3, a scorpion toxin with two putative functional faces separately active on A-type K+ and HERG currents., Huys I, Xu CQ, Wang CZ, Vacher H, Martin-Eauclaire MF, Chi CW, Tytgat J., Biochem J. March 15, 2004; 378 (Pt 3): 745-52.
	Compound mutations: a common cause of severe long-QT syndrome., Westenskow P, Splawski I, Timothy KW, Keating MT, Sanguinetti MC., Circulation. April 20, 2004; 109 (15): 1834-41.
	Inactivation gating determines drug potency: a common mechanism for drug blockade of HERG channels., Yang BF, Xu DH, Xu CQ, Li Z, Du ZM, Wang HZ, Dong DL., Acta Pharmacol Sin. May 1, 2004; 25 (5): 554-60.
	Acidification alters antiarrhythmic drug blockade of the ether-a-go-go-related Gene (HERG) Channels., Dong DL, Li Z, Wang HZ, Du ZM, Song WH, Yang BF., Basic Clin Pharmacol Toxicol. May 1, 2004; 94 (5): 209-12.
	Molecular determinants for high-affinity block of human EAG potassium channels by antiarrhythmic agents., Gessner G, Zacharias M, Bechstedt S, Schönherr R, Heinemann SH., Mol Pharmacol. May 1, 2004; 65 (5): 1120-9.
	Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin., Thomas D, Wimmer AB, Wu K, Hammerling BC, Ficker EK, Kuryshev YA, Kiehn J, Katus HA, Schoels W, Karle CA., Naunyn Schmiedebergs Arch Pharmacol. May 1, 2004; 369 (5): 462-72.
	Block of HERG human K(+) channel and IKr of guinea pig cardiomyocytes by chlorpromazine., Lee SY, Choi SY, Youm JB, Ho WK, Earm YE, Lee CO, Lee CO, Jo SH., J Cardiovasc Pharmacol. May 1, 2004; 43 (5): 706-14.
	Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action., Thomas D, Hammerling BC, Wu K, Wimmer AB, Ficker EK, Kirsch GE, Kochan MC, Wible BA, Scholz EP, Zitron E, Kathöfer S, Kreye VA, Katus HA, Schoels W, Karle CA, Kiehn J., Br J Pharmacol. June 1, 2004; 142 (3): 485-94.
	Activation properties of Kv4.3 channels: time, voltage and [K+]o dependence., Wang S, Bondarenko VE, Qu Y, Morales MJ, Rasmusson RL, Strauss HC., J Physiol. June 15, 2004; 557 (Pt 3): 705-17.
	Comparison of kinetic properties of quinidine and dofetilide block of HERG channels., Tsujimae K, Suzuki S, Yamada M, Kurachi Y., Eur J Pharmacol. June 16, 2004; 493 (1-3): 29-40.
	Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel., Subbiah RN, Clarke CE, Smith DJ, Zhao J, Campbell TJ, Vandenberg JI., J Physiol. July 15, 2004; 558 (Pt 2): 417-31.
	Inhibition of cardiac HERG potassium channels by the atypical antidepressant trazodone., Zitron E, Kiesecker C, Scholz E, Lück S, Bloehs R, Kathöfer S, Thomas D, Kiehn J, Kreye VA, Katus HA, Schoels W, Karle CA., Naunyn Schmiedebergs Arch Pharmacol. August 1, 2004; 370 (2): 146-56.
	Ranolazine: ion-channel-blocking actions and in vivo electrophysiological effects., Schram G, Zhang L, Derakhchan K, Ehrlich JR, Belardinelli L, Nattel S., Br J Pharmacol. August 1, 2004; 142 (8): 1300-8.
	Structural determinants of HERG channel block by clofilium and ibutilide., Perry M, de Groot MJ, Helliwell R, Leishman D, Tristani-Firouzi M, Sanguinetti MC, Mitcheson J., Mol Pharmacol. August 1, 2004; 66 (2): 240-9.
	Probucol aggravates long QT syndrome associated with a novel missense mutation M124T in the N-terminus of HERG., Hayashi K, Shimizu M, Ino H, Yamaguchi M, Terai H, Hoshi N, Higashida H, Terashima N, Uno Y, Kanaya H, Mabuchi H., Clin Sci (Lond). August 1, 2004; 107 (2): 175-82.
	Effects of the atrial antiarrhythmic drug AVE0118 on cardiac ion channels., Gögelein H, Brendel J, Steinmeyer K, Strübing C, Picard N, Rampe D, Kopp K, Busch AE, Bleich M., Naunyn Schmiedebergs Arch Pharmacol. September 1, 2004; 370 (3): 183-92.
	The low-potency, voltage-dependent HERG blocker propafenone--molecular determinants and drug trapping., Witchel HJ, Dempsey CE, Sessions RB, Perry M, Milnes JT, Hancox JC, Mitcheson JS., Mol Pharmacol. November 1, 2004; 66 (5): 1201-12.
	Identification and characterisation of a novel KCNQ1 mutation in a family with Romano-Ward syndrome., Zehelein J, Thomas D, Khalil M, Wimmer AB, Koenen M, Licka M, Wu K, Kiehn J, Brockmeier K, Kreye VA, Karle CA, Katus HA, Ulmer HE, Schoels W., Biochim Biophys Acta. November 5, 2004; 1690 (3): 185-92.
	Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action., Kiesecker C, Zitron E, Lück S, Bloehs R, Scholz EP, Kathöfer S, Thomas D, Kreye VA, Katus HA, Schoels W, Karle CA, Kiehn J., Naunyn Schmiedebergs Arch Pharmacol. December 1, 2004; 370 (6): 423-35.
	Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels., Craven KB, Zagotta WN., J Gen Physiol. December 1, 2004; 124 (6): 663-77.
	Block of wild-type and inactivation-deficient human ether-a-go-go-related gene K+ channels by halofantrine., Sánchez-Chapula JA, Navarro-Polanco RA, Sanguinetti MC., Naunyn Schmiedebergs Arch Pharmacol. December 1, 2004; 370 (6): 484-91.
	Gating charges in the activation and inactivation processes of the HERG channel., Zhang M, Liu J, Tseng GN., J Gen Physiol. December 1, 2004; 124 (6): 703-18.
	Direct block of hERG potassium channels by the protein kinase C inhibitor bisindolylmaleimide I (GF109203X)., Thomas D, Hammerling BC, Wimmer AB, Wu K, Ficker E, Kuryshev YA, Scherer D, Kiehn J, Katus HA, Schoels W, Karle CA., Cardiovasc Res. December 1, 2004; 64 (3): 467-76.
	Activation of cardiac human ether-a-go-go related gene potassium currents is regulated by alpha(1A)-adrenoceptors., Thomas D, Wu K, Wimmer AB, Zitron E, Hammerling BC, Kathöfer S, Lueck S, Bloehs R, Kreye VA, Kiehn J, Katus HA, Schoels W, Karle CA., J Mol Med (Berl). December 1, 2004; 82 (12): 826-37.
	Structure-function studies of the outer mouth and voltage sensor domain of hERG., Tseng GN, Guy HR., Novartis Found Symp. January 1, 2005; 266 19-35; discussion 35-45.
	A mechanism for the potential proarrhythmic effect of acidosis, bradycardia, and hypokalemia on the blockade of human ether-a-go-go-related gene (HERG) channels., Lin C, Cvetanovic I, Ke X, Ranade V, Somberg J., Am J Ther. January 1, 2005; 12 (4): 328-36.
	Effect of beta-adrenoceptor blockers on human ether-a-go-go-related gene (HERG) potassium channels., Dupuis DS, Klaerke DA, Olesen SP., Basic Clin Pharmacol Toxicol. February 1, 2005; 96 (2): 123-30.
	QTc prolongation by grapefruit juice and its potential pharmacological basis: HERG channel blockade by flavonoids., Zitron E, Scholz E, Owen RW, Lück S, Kiesecker C, Thomas D, Kathöfer S, Niroomand F, Kiehn J, Kreye VA, Katus HA, Schoels W, Karle CA., Circulation. February 22, 2005; 111 (7): 835-8.
	The influence of extracellular acidosis on the effect of IKr blockers., Lin C, Ke X, Cvetanovic I, Ranade V, Somberg J., J Cardiovasc Pharmacol Ther. March 1, 2005; 10 (1): 67-76.
	Inhibition of human ether-a-go-go-related gene K+ channel and IKr of guinea pig cardiomyocytes by antipsychotic drug trifluoperazine., Choi SY, Koh YS, Jo SH., J Pharmacol Exp Ther. May 1, 2005; 313 (2): 888-95.
	Modulating effect of ginseng saponins on heterologously expressed HERG currents in Xenopus oocytes., Kim CS, Son SJ, Kim HS, Kim YD, Lee KS, Jeon BH, Kim KJ, Park JK, Park JB., Acta Pharmacol Sin. May 1, 2005; 26 (5): 551-8.
	Inhibition of cardiac HERG channels by grapefruit flavonoid naringenin: implications for the influence of dietary compounds on cardiac repolarisation., Scholz EP, Zitron E, Kiesecker C, Lück S, Thomas D, Kathöfer S, Kreye VA, Katus HA, Kiehn J, Schoels W, Karle CA., Naunyn Schmiedebergs Arch Pharmacol. June 1, 2005; 371 (6): 516-25.
	In vivo targeting of ERG potassium channels in mice and dogs by a positron-emitting analogue of fluoroclofilium., Kim SW, Yang SD, Ahn BJ, Park JH, Lee DS, Gessner G, Heinemann SH, Herdering W, Yu KH., Exp Mol Med. August 31, 2005; 37 (4): 269-75.
	Molecular mapping of a site for Cd2+-induced modification of human ether-à-go-go-related gene (hERG) channel activation., Fernandez D, Ghanta A, Kinard KI, Sanguinetti MC., J Physiol. September 15, 2005; 567 (Pt 3): 737-55.
	Interactions between charged residues in the transmembrane segments of the voltage-sensing domain in the hERG channel., Zhang M, Liu J, Jiang M, Wu DM, Sonawane K, Guy HR, Tseng GN., J Membr Biol. October 1, 2005; 207 (3): 169-81.
	Inhibitory effect of rhynchophylline on human ether-a-go-go related gene channel., Gui L, Li ZW, Du R, Yuan GH, Li W, Ren FX, Li J, Yang JG., Sheng Li Xue Bao. October 25, 2005; 57 (5): 648-52.
	Functional assessment of compound mutations in the KCNQ1 and KCNH2 genes associated with long QT syndrome., Grunnet M, Behr ER, Calloe K, Hofman-Bang J, Till J, Christiansen M, McKenna WJ, Olesen SP, Schmitt N., Heart Rhythm. November 1, 2005; 2 (11): 1238-49.
	Tryptophan scanning mutagenesis of the HERG K+ channel: the S4 domain is loosely packed and likely to be lipid exposed., Subbiah RN, Kondo M, Campbell TJ, Vandenberg JI., J Physiol. December 1, 2005; 569 (Pt 2): 367-79.
	Involvement of Golgin-160 in cell surface transport of renal ROMK channel: co-expression of Golgin-160 increases ROMK currents., Bundis F, Neagoe I, Schwappach B, Steinmeyer K., Cell Physiol Biochem. January 1, 2006; 17 (1-2): 1-12.
	Block of HERG channels by berberine: mechanisms of voltage- and state-dependence probed with site-directed mutant channels., Rodriguez-Menchaca A, Ferrer-Villada T, Lara J, Fernandez D, Navarro-Polanco RA, Sanchez-Chapula JA., J Cardiovasc Pharmacol. January 1, 2006; 47 (1): 21-9.
	The effects of sevoflurane and propofol on QT interval and heterologously expressed human ether-a-go-go related gene currents in Xenopus oocytes., Yamada M, Hatakeyama N, Malykhina AP, Yamazaki M, Momose Y, Akbarali HI., Anesth Analg. January 1, 2006; 102 (1): 98-103.

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