Papers associated with kcnh2

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	Aconitine blocks HERG and Kv1.5 potassium channels., Li Y, Tu D, Xiao H, Du Y, Zou A, Liao Y, Dong S., J Ethnopharmacol. August 19, 2010; 131 (1): 187-95.
	Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels., Larsen AP, Bentzen BH, Grunnet M., Br J Pharmacol. October 1, 2010; 161 (3): 614-28.
	Response of i(kr) and HERG currents to the antipsychotics tiapride and sulpiride., Jo SH, Lee SY., Korean J Physiol Pharmacol. October 1, 2010; 14 (5): 305-10.
	Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels., Van Slyke AC, Rezazadeh S, Snopkowski M, Shi P, Allard CR, Claydon TW., Biophys J. November 3, 2010; 99 (9): 2841-52.
	A potent potassium channel blocker from Mesobuthus eupeus scorpion venom., Gao B, Peigneur S, Tytgat J, Zhu S., Biochimie. December 1, 2010; 92 (12): 1847-53.
	Molecular determinants of human ether-à-go-go-related gene 1 (hERG1) K+ channel activation by NS1643., Grunnet M, Abbruzzese J, Sachse FB, Sanguinetti MC., Mol Pharmacol. January 1, 2011; 79 (1): 1-9.
	hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine., Staudacher I, Wang L, Wan X, Obers S, Wenzel W, Tristram F, Koschny R, Staudacher K, Kisselbach J, Koelsch P, Schweizer PA, Katus HA, Ficker E, Thomas D., Naunyn Schmiedebergs Arch Pharmacol. February 1, 2011; 383 (2): 119-39.
	hERG potassium channel gating is mediated by N- and C-terminal region interactions., Gustina AS, Trudeau MC., J Gen Physiol. March 1, 2011; 137 (3): 315-25.
	Recombinant expression of the toxic peptide ErgTx1 and role of Met35 on its stability and function., Jimenez-Vargas JM, Restano-Cassulini R, Quintero-Hernández V, Gurrola GB, Possani LD., Peptides. March 1, 2011; 32 (3): 560-7.
	Trapping and dissociation of propafenone derivatives in HERG channels., Windisch A, Timin E, Schwarz T, Stork-Riedler D, Erker T, Ecker G, Hering S., Br J Pharmacol. April 1, 2011; 162 (7): 1542-52.
	HERG channel inhibitors in extracts of Coptidis rhizoma., Schramm A, Baburin I, Hering S, Hamburger M., Planta Med. May 1, 2011; 77 (7): 692-7.
	hERGAPDbase: a database documenting hERG channel inhibitory potentials and APD-prolongation activities of chemical compounds., Hishigaki H, Kuhara S., Database (Oxford). May 17, 2011; 2011 bar017.
	Demonstration of physical proximity between the N terminus and the S4-S5 linker of the human ether-a-go-go-related gene (hERG) potassium channel., de la Peña P, Alonso-Ron C, Machín A, Fernández-Trillo J, Carretero L, Domínguez P, Barros F., J Biol Chem. May 27, 2011; 286 (21): 19065-75.
	Differential effects of ginsenoside metabolites on HERG k channel currents., Choi SH, Shin TJ, Hwang SH, Lee BH, Kang J, Kim HJ, Oh JW, Bae CS, Lee SH, Nah SY., J Ginseng Res. June 1, 2011; 35 (2): 191-9.
	A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties., Peigneur S, Billen B, Derua R, Waelkens E, Debaveye S, Béress L, Tytgat J., Biochem Pharmacol. July 1, 2011; 82 (1): 81-90.
	Ginsenoside Rg(3) decelerates hERG K(+) channel deactivation through Ser631 residue interaction., Choi SH, Shin TJ, Hwang SH, Lee BH, Kang J, Kim HJ, Jo SH, Choe H, Nah SY., Eur J Pharmacol. August 1, 2011; 663 (1-3): 59-67.
	Functional characterization of the LQT2-causing mutation R582C and the associated voltage-dependent fluorescence signal., Fougere RR, Es-Salah-Lamoureux Z, Rezazadeh S, Eldstrom J, Fedida D., Heart Rhythm. August 1, 2011; 8 (8): 1273-80.
	Blockade of permeation by potassium but normal gating of the G628S nonconducting hERG channel mutant., Es-Salah-Lamoureux Z, Xiong PY, Goodchild SJ, Ahern CA, Fedida D., Biophys J. August 3, 2011; 101 (3): 662-70.
	Sig1R protein regulates hERG channel expression through a post-translational mechanism in leukemic cells., Crottès D, Martial S, Rapetti-Mauss R, Pisani DF, Loriol C, Pellissier B, Martin P, Chevet E, Borgese F, Soriani O., J Biol Chem. August 12, 2011; 286 (32): 27947-58.
	Effects of the histamine H(1) receptor antagonist hydroxyzine on hERG K(+) channels and cardiac action potential duration., Lee BH, Lee SH, Chu D, Hyun JW, Choe H, Choi BH, Jo SH., Acta Pharmacol Sin. September 1, 2011; 32 (9): 1128-37.
	Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide., Garg V, Stary-Weinzinger A, Sachse F, Sanguinetti MC., Mol Pharmacol. October 1, 2011; 80 (4): 630-7.
	Strong activation of ether-à-go-go-related gene 1 K+ channel isoforms by NS1643 in human embryonic kidney 293 and Chinese hamster ovary cells., Schuster AM, Glassmeier G, Bauer CK., Mol Pharmacol. November 1, 2011; 80 (5): 930-42.
	A mechanism underlying compound-induced voltage shift in the current activation of hERG by antiarrhythmic agents., Furutani K, Yamakawa Y, Inanobe A, Iwata M, Ohno Y, Kurachi Y., Biochem Biophys Res Commun. November 11, 2011; 415 (1): 141-6.
	Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathway., Ferrer T, Cordero-Morales JF, Arias M, Ficker E, Medovoy D, Perozo E, Tristani-Firouzi M., J Biol Chem. November 11, 2011; 286 (45): 39091-9.
	Stimulation of HERG channel activity by β-catenin., Munoz C, Saxena A, Pakladok T, Bogatikov E, Wilmes J, Seebohm G, Föller M, Lang F., PLoS One. January 1, 2012; 7 (8): e43353.
	A molecular switch driving inactivation in the cardiac K+ channel HERG., Köpfer DA, Hahn U, Ohmert I, Vriend G, Pongs O, de Groot BL, Zachariae U., PLoS One. January 1, 2012; 7 (7): e41023.
	Pharmacophore modeling for hERG channel facilitation., Yamakawa Y, Furutani K, Inanobe A, Ohno Y, Kurachi Y., Biochem Biophys Res Commun. February 3, 2012; 418 (1): 161-6.
	Identification and functional characterization of the novel human ether-a-go-go-related gene (hERG) R744P mutant associated with hereditary long QT syndrome 2., Aidery P, Kisselbach J, Gaspar H, Baldea I, Schweizer PA, Becker R, Katus HA, Thomas D., Biochem Biophys Res Commun. February 24, 2012; 418 (4): 830-5.
	18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels., Du YM, Xia CK, Zhao N, Dong Q, Lei M, Xia JH., Acta Pharmacol Sin. June 1, 2012; 33 (6): 752-60.
	Proton block of the pore underlies the inhibition of hERG cardiac K+ channels during acidosis., Van Slyke AC, Cheng YM, Mafi P, Allard CR, Hull CM, Shi YP, Claydon TW., Am J Physiol Cell Physiol. June 15, 2012; 302 (12): C1797-806.
	Acute alteration of cardiac ECG, action potential, I(Kr) and the human ether-a-go-go-related gene (hERG) K+ channel by PCB 126 and PCB 77., Park MH, Park WS, Jo SH., Toxicol Appl Pharmacol. July 1, 2012; 262 (1): 60-9.
	Inhibition of cardiac Kir2.1-2.3 channels by beta3 adrenoreceptor antagonist SR 59230A., Kulzer M, Seyler C, Welke F, Scherer D, Xynogalos P, Scholz EP, Thomas D, Becker R, Karle CA, Katus HA, Zitron E., Biochem Biophys Res Commun. July 27, 2012; 424 (2): 315-20.
	Coexisting mutations/polymorphisms of the long QT syndrome genes in patients with repaired Tetralogy of Fallot are associated with the risks of life-threatening events., Chiu SN, Wu MH, Su MJ, Wang JK, Lin MT, Chang CC, Hsu HW, Shen CT, Thériault O, Chahine M., Hum Genet. August 1, 2012; 131 (8): 1295-304.
	Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule., Garg V, Sachse FB, Sanguinetti MC., J Gen Physiol. September 1, 2012; 140 (3): 307-24.
	Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels., Tan PS, Perry MD, Ng CA, Vandenberg JI, Hill AP., J Gen Physiol. September 1, 2012; 140 (3): 293-306.
	Marine algal toxin azaspiracid is an open-state blocker of hERG potassium channels., Twiner MJ, Doucette GJ, Rasky A, Huang XP, Roth BL, Sanguinetti MC., Chem Res Toxicol. September 17, 2012; 25 (9): 1975-84.
	Kcnh1 voltage-gated potassium channels are essential for early zebrafish development., Stengel R, Rivera-Milla E, Sahoo N, Ebert C, Bollig F, Heinemann SH, Schönherr R, Englert C., J Biol Chem. October 12, 2012; 287 (42): 35565-35575.
	A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxins., Peigneur S, Béress L, Möller C, Marí F, Forssmann WG, Tytgat J., FASEB J. December 1, 2012; 26 (12): 5141-51.
	Impaired ion channel function related to a common KCNQ1 mutation - implications for risk stratification in long QT syndrome 1., Aidery P, Kisselbach J, Schweizer PA, Becker R, Katus HA, Thomas D., Gene. December 10, 2012; 511 (1): 26-33.
	Blocking of the human ether-à-go-go-related gene channel by imatinib mesylate., Dong Q, Fu XX, Du LL, Zhao N, Xia CK, Yu KW, Cheng LX, Du YM., Biol Pharm Bull. January 1, 2013; 36 (2): 268-75.
	PIKfyve sensitivity of hERG channels., Pakladok T, Almilaji A, Munoz C, Alesutan I, Lang F., Cell Physiol Biochem. January 1, 2013; 31 (6): 785-94.
	The eag domain regulates hERG channel inactivation gating via a direct interaction., Gustina AS, Trudeau MC., J Gen Physiol. February 1, 2013; 141 (2): 229-41.
	Block of hERG K+ channel and prolongation of action potential duration by fluphenazine at submicromolar concentration., Hong HK, Lee BH, Park MH, Lee SH, Chu D, Kim WJ, Choe H, Hee Choi B, Jo SH., Eur J Pharmacol. February 28, 2013; 702 (1-3): 165-73.
	Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells., Jehle J, Ficker E, Wan X, Deschenes I, Kisselbach J, Wiedmann F, Staudacher I, Schmidt C, Schweizer PA, Becker R, Katus HA, Thomas D., Br J Pharmacol. March 1, 2013; 168 (5): 1215-29.
	Pore helices play a dynamic role as integrators of domain motion during Kv11.1 channel inactivation gating., Perry MD, Ng CA, Vandenberg JI., J Biol Chem. April 19, 2013; 288 (16): 11482-91.
	Mapping of interactions between the N- and C-termini and the channel core in HERG K+ channels., de la Peña P, Machín A, Fernández-Trillo J, Domínguez P, Barros F., Biochem J. May 1, 2013; 451 (3): 463-74.
	ZC88, a novel 4-amino piperidine analog, inhibits the growth of neuroblastoma cells through blocking hERG potassium channel., Wei X, Sun H, Yan H, Zhang C, Zhang S, Liu X, Hua N, Ma X, Zheng J., Cancer Biol Ther. May 1, 2013; 14 (5): 450-7.
	VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus., Ciau-Uitz A, Pinheiro P, Kirmizitas A, Zuo J, Patient R., Development. June 1, 2013; 140 (12): 2632-42.
	External pH modulates EAG superfamily K+ channels through EAG-specific acidic residues in the voltage sensor., Kazmierczak M, Zhang X, Chen B, Mulkey DK, Shi Y, Wagner PG, Pivaroff-Ward K, Sassic JK, Bayliss DA, Jegla T., J Gen Physiol. June 1, 2013; 141 (6): 721-35.
	Klotho sensitivity of the hERG channel., Munoz C, Pakladok T, Almilaji A, Elvira B, Seebohm G, Voelkl J, Föller M, Shumilina E, Lang F., FEBS Lett. June 5, 2013; 587 (11): 1663-8.

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