Evidence for an alternate model of human P-glycoprotein structure and biogenesis. J Biol Chem. April 5, 1993; 268 (10): 6903-8.
Protein kinase C transiently activated heteromeric N-methyl-D-aspartate receptor channels independent of the phosphorylatable C-terminal splice domain and of consensus phosphorylation sites. J Biol Chem. March 18, 1994; 269 (11): 8204-8.
Transmembrane orientation and topogenesis of the third and fourth membrane-spanning regions of human P-glycoprotein (MDR1). Cancer Res. June 15, 1994; 54 (12): 3202-9.
Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins. Neuron. December 1, 1994; 13 (6): 1345-57.
A novel tropomyosin isoform encoded by the Xenopus laevis Thézé N , Lerivray H, Hardy S , Lepetit D, Thiébaud P ., Gene. January 30, 1998; 207 (2): 235-9.
Subunit mutations affect ethanol actions on GABA(A) receptors expressed in Xenopus oocytes. Ueno S , Wick MJ, Ye Q, Harrison NL, Harris RA., Br J Pharmacol. May 1, 1999; 127 (2): 377-82.
Amino acid volume and hydropathy of a transmembrane site determine glycine and anesthetic sensitivity of glycine receptors. J Biol Chem. August 13, 1999; 274 (33): 23006-12.
Two skeletal alpha-tropomyosin transcripts with distinct 3'UTR have different temporal and spatial patterns of expression in the striated muscle lineages of Xenopus laevis. Hardy S , Hamon S, Cooper B, Mohun T, Thiébaud P ., Mech Dev. September 1, 1999; 87 (1-2): 199-202.
The actions of ether, alcohol and alkane general anaesthetics on Br J Pharmacol. February 1, 2000; 129 (4): 731-43.
Reorientation of Mol Biol Cell. September 1, 2000; 11 (9): 2973-85.
Benzodiazepines act on Nat Neurosci. December 1, 2000; 3 (12): 1274-81.
Ethanol inhibition of N-methyl-D-aspartate receptors is reduced by site-directed mutagenesis of a transmembrane domain phenylalanine residue. J Biol Chem. November 30, 2001; 276 (48): 44729-35.
Structural basis for activation of G-protein-coupled receptors. Pharmacol Toxicol. December 1, 2002; 91 (6): 304-12.
Acetylcholine and alcohol sensitivity of neuronal nicotinic acetylcholine receptors: mutations in transmembrane domains. Alcohol Clin Exp Res. December 1, 2002; 26 (12): 1764-72.
Xenopus Chanoine C , Hardy S ., Dev Dyn. January 1, 2003; 226 (1): 12-23.
A new Epilepsia. July 1, 2003; 44 (7): 981-5.
Single-channel SCAM identifies pore-lining residues in the first extracellular loop and first transmembrane domains of J Gen Physiol. October 1, 2003; 122 (4): 389-405.
Tryptophan substitutions reveal the role of nicotinic acetylcholine receptor alpha- Biochemistry. January 13, 2004; 43 (1): 78-84.
Mechanism of proton gating of a urea channel. Weeks DL , Gushansky G, Scott DR, Sachs G., J Biol Chem. March 12, 2004; 279 (11): 9944-50.
Salicylidene salicylhydrazide, a selective inhibitor of beta 1-containing Br J Pharmacol. May 1, 2004; 142 (1): 97-106.
Cross-linking of glycine receptor transmembrane segments two and three alters coupling of ligand binding with channel opening. J Neurochem. August 1, 2004; 90 (4): 962-9.
Channel gating of the glycine receptor changes accessibility to residues implicated in receptor potentiation by alcohols and anesthetics. J Biol Chem. August 6, 2004; 279 (32): 33919-27.
Tryptophan scanning mutagenesis in the Biochemistry. August 10, 2004; 43 (31): 10064-70.
P2Y(1) receptor modulation of endogenous ion channel function in Xenopus oocytes: Involvement of transmembrane domains. Purinergic Signal. December 1, 2004; 1 (1): 75-81.
Exploration of the extracellular space by a large-scale secretion screen in the early Xenopus Pera EM , Hou S, Strate I, Wessely O , De Robertis EM ., Int J Dev Biol. January 1, 2005; 49 (7): 781-96.
Differential stability of biogenesis intermediates reveals a common pathway for J Biol Chem. January 7, 2005; 280 (1): 261-9.
An atlas of differential gene expression during early Xenopus embryogenesis. Pollet N , Muncke N, Verbeek B, Li Y, Fenger U, Delius H, Niehrs C ., Mech Dev. March 1, 2005; 122 (3): 365-439.
The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining Mol Membr Biol. January 1, 2006; 23 (6): 486-98.
Sites in TM2 and 3 are critical for alcohol-induced conformational changes in GABA receptors. J Neurochem. February 1, 2006; 96 (3): 885-92.
Effects of anesthetics on mutant N-methyl-D-aspartate receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther. July 1, 2006; 318 (1): 434-43.
The residues determining differences in ion affinities among the alternative splice variants F, A, and B of the mammalian renal Na-K-Cl cotransporter ( J Biol Chem. March 2, 2007; 282 (9): 6540-7.
Effects of a mutation in the TM2- Dev Biol. June 4, 2007; 1152 1-9.
Cross-linking of sites involved with alcohol action between transmembrane segments 1 and 3 of the glycine receptor following activation. J Neurochem. March 1, 2008; 104 (6): 1649-62.
Human nocturnal frontal lobe epilepsy: pharmocogenomic profiles of pathogenic nicotinic acetylcholine receptor beta-subunit mutations outside the ion channel pore. Mol Pharmacol. August 1, 2008; 74 (2): 379-91.
The role of residues in binding loop A in desflurane and propofol modulation of recombinant 5-HT3A receptor. Kim MK , Yang J , Min KT., Neurosci Lett. November 13, 2009; 465 (2): 147-50.
Linking of Glycine Receptor Transmembrane Segments Three and Four Allows Assignment of Intrasubunit-Facing Residues. ACS Chem Neurosci. July 1, 2010; 1 (7): 482.
Nicotinic acetylcholine receptor transmembrane mutations convert ivermectin from a positive to a negative allosteric modulator. Mol Pharmacol. August 1, 2010; 78 (2): 198-204.
SCAM analysis of Wang J , Dahl G., J Gen Physiol. November 1, 2010; 136 (5): 515-27.
Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2- Lynch JW ., J Biol Chem. December 17, 2010; 285 (51): 40373-86.
Mutations in the transmembrane domain M3 generate spontaneously open orphan glutamate δ1 receptor. Dev Biol. March 25, 2011; 1382 1-8.
A mutant residue in the third transmembrane region of the GABA(A) alpha1 subunit causes increased agonistic neurosteroid responses. Neurochem Int. June 1, 2011; 58 (7): 794-803.
Conserved residues in the extracellular loops of short-wavelength cone visual pigments. Knox BE ., Biochemistry. August 16, 2011; 50 (32): 6763-73.
Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization. Neuropharmacology. December 1, 2011; 61 (8): 1306-13.
Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols. J Pharmacol Exp Ther. February 1, 2012; 340 (2): 304-16.
Cystic fibrosis transmembrane conductance regulator: a molecular model defines the architecture of the anion conduction path and locates a "bottleneck" in the pore. Biochemistry. March 20, 2012; 51 (11): 2199-212.
The N-terminal half of the connexin protein contains the core elements of the pore and voltage gates. J Membr Biol. August 1, 2012; 245 (8): 453-63.
The importance of being aromatic: π interactions in sodium symporters. Biochemistry. November 27, 2012; 51 (47): 9480-7.
Analysis of trafficking, stability and function of human PLoS One. January 1, 2013; 8 (8): e70916.
The relative orientation of the Han L , Talwar S, Lynch JW ., ACS Chem Neurosci. February 20, 2013; 4 (2): 248-54.
Structural model of the J Biol Chem. September 13, 2013; 288 (37): 26372-84.
