The pappa gene encodes a secreted metallopeptidase protein localized to the extracellular space. It functions by cleaving insulin-like growth factor binding proteins (IGFBPs), thereby modulating the ac...[+]

The pappa gene encodes a secreted metallopeptidase protein localized to the extracellular space. It functions by cleaving insulin-like growth factor binding proteins (IGFBPs), thereby modulating the activity of insulin-like growth factors which are involved in developmental processes. Expression is observed during embryogenesis with transcripts detected in the developing eye, somites, and other tissues. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD