The timp2 protein is a tissue inhibitor of metalloproteinases that functions as an extracellular matrix regulator by inhibiting matrix metalloproteinase activity. It is expressed during embryogenesis i...[+]

The timp2 protein is a tissue inhibitor of metalloproteinases that functions as an extracellular matrix regulator by inhibiting matrix metalloproteinase activity. It is expressed during embryogenesis in structures including the developing eye, otic vesicle, branchial arches, notochord, and pronephros. Expression is also observed in the neural crest and central nervous system. The protein operates within the extracellular space to modulate proteolysis and support tissue morphogenesis. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD