The sema3b gene encodes a secreted class 3 semaphorin protein functioning as a guidance cue for specific axons in the developing nervous system. In xenopus, sema3b acts as a chemorepellent for retinal ...[+]

The sema3b gene encodes a secreted class 3 semaphorin protein functioning as a guidance cue for specific axons in the developing nervous system. In xenopus, sema3b acts as a chemorepellent for retinal ganglion cell axons and olfactory placode-derived neurons, influencing their pathfinding. It is expressed in the cranial ganglia, branchial arches, eye, and cement gland during embryogenesis. The protein signals through neuropilin-plexin receptor complexes to mediate its axonal guidance effects. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD