Zic3 is a zinc finger transcription factor that functions as a transcriptional regulator in Xenopus laevis and Xenopus tropicalis. It is involved in neural development, including neural tube formation,...[+]

Zic3 is a zinc finger transcription factor that functions as a transcriptional regulator in Xenopus laevis and Xenopus tropicalis. It is involved in neural development, including neural tube formation, neural crest development, and neural crest cell migration. Zic3 also plays a role in establishing left-right asymmetry during embryogenesis. It is expressed in the neural tube, neural crest, and other tissues, where it regulates genes involved in neural patterning and development. Zic3 acts as a transcriptional activator or repressor, influencing processes such as neural tube closure and neural crest specification. [-]

             X-linked VACTERL association

          VACTERL ASSOCIATION, X-LINKED, WITH OR WITHOUT HYDROCEPHALUS; VACTERLX

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD