Gene plgrkt encodes a plasminogen receptor with a c-terminal lysine transmembrane protein. The protein localizes to the cell membrane and functions in binding plasminogen, facilitating its activation t...[+]

Gene plgrkt encodes a plasminogen receptor with a c-terminal lysine transmembrane protein. The protein localizes to the cell membrane and functions in binding plasminogen, facilitating its activation to plasmin on the cell surface which is involved in extracellular matrix degradation and cell migration processes during development. Expression is detected in the epidermis, neural crest, and other migratory cell populations. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD