The qrfpr gene encodes a g-protein coupled receptor that binds the neuropeptide qrfp (pyroglutamylated arginine-phenylalanine-amide peptide). The protein is involved in the regulation of feeding behavi...[+]

The qrfpr gene encodes a g-protein coupled receptor that binds the neuropeptide qrfp (pyroglutamylated arginine-phenylalanine-amide peptide). The protein is involved in the regulation of feeding behavior and energy homeostasis. It is expressed within the brain, specifically in the hypothalamus, diencephalon, and spinal cord. This receptor functions as a neuromodulator and its activation influences locomotor activity. Expression is also detected in melanocytes, suggesting a role in pigmentation regulation. The protein is localized to the cell membrane. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD