The fos gene encodes a bZIP transcription factor protein localized to the nucleus. It forms heterodimers with jun family proteins to create the AP-1 transcription complex, which binds DNA at specific p...[+]

The fos gene encodes a bZIP transcription factor protein localized to the nucleus. It forms heterodimers with jun family proteins to create the AP-1 transcription complex, which binds DNA at specific promoter elements to regulate target gene expression. This protein is involved in processes including cell proliferation, differentiation, and neural development. Expression is induced by various stimuli and is documented in tissues such as the brain, spinal cord, notochord, cement gland, eye, branchial arches, and pronephros during embryonic stages. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD