The gene dock1 encodes a guanine nucleotide exchange factor protein that localizes to the cytoplasm and nucleus. It functions in rac1 GTPase binding and rac guanyl-nucleotide exchange factor activity, ...[+]

The gene dock1 encodes a guanine nucleotide exchange factor protein that localizes to the cytoplasm and nucleus. It functions in rac1 GTPase binding and rac guanyl-nucleotide exchange factor activity, facilitating the exchange of GDP for GTP on rac family small GTPases. This activity is involved in cell migration processes during embryonic development, particularly in the neural crest, craniofacial structures, and the pronephros. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD