The pttg1ip gene encodes a protein that is a transcription cofactor, interacting with the pituitary tumor-transforming gene 1 (pttg1) protein. This interaction occurs in the nucleus where the pttg1ip p...[+]

The pttg1ip gene encodes a protein that is a transcription cofactor, interacting with the pituitary tumor-transforming gene 1 (pttg1) protein. This interaction occurs in the nucleus where the pttg1ip protein is localized. The pttg1-pttg1ip complex functions to regulate the expression of specific target genes involved in cell cycle progression and mitosis during embryonic development, including stages from gastrulation through organogenesis. Expression is detected in the developing brain, neural tube, eye, branchial arches, and somites. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD