The nrg4 gene encodes a transmembrane protein that is proteolytically cleaved to release an extracellular EGF-like signaling molecule. The full-length protein localizes to the cell membrane, and the cl...[+]

The nrg4 gene encodes a transmembrane protein that is proteolytically cleaved to release an extracellular EGF-like signaling molecule. The full-length protein localizes to the cell membrane, and the cleaved fragment functions in the extracellular space. During embryogenesis, nrg4 mRNA is expressed in the neural tube and somites. [-]

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