The adra2a gene encodes a g-protein coupled receptor. The protein localizes to the plasma membrane and binds catecholamines like norepinephrine. Its function involves coupling to gi proteins to inhibit...[+]

The adra2a gene encodes a g-protein coupled receptor. The protein localizes to the plasma membrane and binds catecholamines like norepinephrine. Its function involves coupling to gi proteins to inhibit adenylate cyclase activity, resulting in decreased intracellular camp levels. Expression is documented in melanotrope cells of the pituitary gland in tadpoles, and within the brain including the telencephalon, diencephalon, mesencephalon, and retina. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD