The dock4 protein functions as a guanine nucleotide exchange factor (gef) for rac gtpases. It localizes to the cytoplasm and membrane ruffles where it activates rac1 to regulate cytoskeletal reorganiza...[+]

The dock4 protein functions as a guanine nucleotide exchange factor (gef) for rac gtpases. It localizes to the cytoplasm and membrane ruffles where it activates rac1 to regulate cytoskeletal reorganization during cell migration. This activity is involved in the collective migration of neural crest cells, contributing to the formation of structures such as the cranial ganglia and branchial arches. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD